AMPDB_4299 | Defensin

PEPTIDE SUMMARY

Defensin

1 General Description

AMPDB ID: AMPDB_4299

Protein Names: Defensin

Protein Family: Invertebrate defensin family; Type 1 subfamily

Gene Name: Nil

Source Organism: Trypoxylus dichotomus (Japanese rhinoceros beetle) (Allomyrina dichotoma)

Protein Length: 43 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

VTCDLLSFEAKGFAANHSLCAAHCLAIGRRGGSCERGVCICRR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 6, 'R': 5, 'N': 1, 'D': 1, 'C': 6, 'Q': 0, 'E': 2, 'G': 5, 'H': 2, 'I': 2, 'L': 4, 'K': 1, 'M': 0, 'F': 2, 'P': 0, 'S': 3, 'T': 1, 'W': 0, 'Y': 0, 'V': 2

Frequencies of Amino Acids

'A': 13.95%, 'R': 11.63%, 'N': 2.33%, 'D': 2.33%, 'C': 13.95%, 'Q': 0%, 'E': 4.65%, 'G': 11.63%, 'H': 4.65%, 'I': 4.65%, 'L': 9.3%, 'K': 2.33%, 'M': 0%, 'F': 4.65%, 'P': 0%, 'S': 6.98%, 'T': 2.33%, 'W': 0%, 'Y': 0%, 'V': 4.65%

Missing Amino Acid(s)

M, P, Q, W, Y

Most Occurring Amino Acid(s)

A, C

Less Occurring Amino Acid(s)

D, K, N, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	4553.31 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	81.861	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	45.947	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.281	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.558	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.394	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.812	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.233, 0.209, 0.279 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.047	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 375	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Staphylococcus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-MRSA, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Miyanoshita A, Hara S, Sugiyama M, et al. Isolation and characterization of a new member of the insect defensin family from a beetle, Allomyrina dichotoma. Biochem Biophys Res Commun. 1996;220(3):526-31. Published 1996 Mar 27. doi:10.1006/bbrc.1996.0438

PMID: 8607799

5.2 Protein Sequence Databases

UniProt: Q10745

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q10745

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR017982, IPR001542, IPR003614, IPR036574

PANTHER: Not found

PROSITE: PS51378

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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