AMPDB_4274 | Alpha-defensin PhD-4

PEPTIDE SUMMARY

Alpha-defensin PhD-4

1 General Description

AMPDB ID: AMPDB_4274

Protein Names: Alpha-defensin PhD-4

Protein Family: Alpha-defensin family

Gene Name: Nil

Source Organism: Papio hamadryas (Hamadryas baboon)

Protein Length: 30 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

ACYCRIPACFAGERRYGTCFYLGRVWAFCC

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 4, 'R': 4, 'N': 0, 'D': 0, 'C': 6, 'Q': 0, 'E': 1, 'G': 3, 'H': 0, 'I': 1, 'L': 1, 'K': 0, 'M': 0, 'F': 3, 'P': 1, 'S': 0, 'T': 1, 'W': 1, 'Y': 3, 'V': 1

Frequencies of Amino Acids

'A': 13.33%, 'R': 13.33%, 'N': 0%, 'D': 0%, 'C': 20%, 'Q': 0%, 'E': 3.33%, 'G': 10%, 'H': 0%, 'I': 3.33%, 'L': 3.33%, 'K': 0%, 'M': 0%, 'F': 10%, 'P': 3.33%, 'S': 0%, 'T': 3.33%, 'W': 3.33%, 'Y': 10%, 'V': 3.33%

Missing Amino Acid(s)

D, H, K, M, N, Q, S

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

E, I, L, P, T, V, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3487.13 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	49	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	58.683	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.443	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.346	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.375	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.625	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.333, 0.133, 0.2 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.233	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	9970, 10345	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

C.albicans, E.coli (Gram-negative), L.monocytogenes (Gram-positive), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Fungicide, Anti-MRSA, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Stegemann C, Tsvetkova EV, Aleshina GM, et al. De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom. 2010;24(5):599-604. Published 2010 Mar 15. doi:10.1002/rcm.4424

PMID: 20155756

5.2 Protein Sequence Databases

UniProt: P86724

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P86724

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR016327, IPR006081, IPR006080

PANTHER: PTHR11876

PROSITE: PS00269

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

Download