AMPDB_42271 | S-type Pyocin

PEPTIDE SUMMARY

S-type Pyocin

1 General Description

AMPDB ID: AMPDB_42271

Protein Names: S-type Pyocin (S-type pyocin domain-containing protein)

Protein Family: Nil

Gene Name: G7Z27_10550 GJJ08_010600

Source Organism: Klebsiella pneumoniae

Protein Length: 451 AA

Protein Existence: Predicted

2 Protein Sequence & Composition

2.1 Sequence

MTQILGTGEGKTSSVAKEPVVERKPAQVFFESMALAASMSGYYAGPTATTLGNSLSLGAGTAAGVGEGVAGARVLAAPNPLTVALLAIFYSPSLNEGETEMLQNIRGDQLYQNLIHSQMMVGAFTRVNSTVIQGDYVPEYELREIARQNGTVHTRVRFRIEEDPESGELVSRSYEVGEKSGLDRVRVRFAKQLNKETWGFEDPSIKGTFVWSRSAGQGKFEWGSSQTTVHDGGAGGSTTPPTPIPEPRSVWGLPNPAPASLPPVPGTPIPEEQGPNIETLPIEDRDFNDFIIVDPMGGVPAIYVYFQKASVRDLEVDYYGNFEGRSRQGLYEVDHIPSKEAVRIYLKGTYPNLKDDIIEQMTDRVAAVAIPIEVHRQCSETYGGKNNSKFRTQDGGLVTQKVLDASNLEAAVDANWDVNAECLRNEYGVSDEKIEEIRAKLHELNRKAGLY

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 36, 'R': 26, 'N': 20, 'D': 21, 'C': 2, 'Q': 18, 'E': 39, 'G': 44, 'H': 6, 'I': 23, 'L': 31, 'K': 18, 'M': 8, 'F': 14, 'P': 29, 'S': 30, 'T': 27, 'W': 5, 'Y': 17, 'V': 37

Frequencies of Amino Acids

'A': 7.98%, 'R': 5.76%, 'N': 4.43%, 'D': 4.66%, 'C': 0.44%, 'Q': 3.99%, 'E': 8.65%, 'G': 9.76%, 'H': 1.33%, 'I': 5.1%, 'L': 6.87%, 'K': 3.99%, 'M': 1.77%, 'F': 3.1%, 'P': 6.43%, 'S': 6.65%, 'T': 5.99%, 'W': 1.11%, 'Y': 3.77%, 'V': 8.2%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

227

Hydrophilic Amino Acid(s) Count

224

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	49277.2 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	78.47	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	41.246	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.404	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.641	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.734	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-15.522	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.282, 0.273, 0.253 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.08	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	52830, 52955	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Shelenkov A, Mikhaylova Y, Yanushevich Y, et al. Molecular Typing, Characterization of Antimicrobial Resistance, Virulence Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella pneumoniae Isolates. Antibiotics (Basel). 2020;9(5). Published 2020 May 17. doi:10.3390/antibiotics9050261

PMID: 32429555

5.2 Protein Sequence Databases

UniProt: A0A2L0KST4

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A2L0KST4

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	CP049716	GenBank \|\| EMBL
2.	CP063008	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_004200308.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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