AMPDB_4214 | Signiferin-2.1

PEPTIDE SUMMARY

Signiferin-2.1

1 General Description

AMPDB ID: AMPDB_4214

Protein Names: Signiferin-2.1

Protein Family: Nil

Gene Name: Nil

Source Organism: Crinia signifera (Common eastern froglet)

Protein Length: 15 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

IIGHLIKTALGMLGL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 3, 'H': 1, 'I': 3, 'L': 4, 'K': 1, 'M': 1, 'F': 0, 'P': 0, 'S': 0, 'T': 1, 'W': 0, 'Y': 0, 'V': 0

Frequencies of Amino Acids

'A': 6.67%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 20%, 'H': 6.67%, 'I': 20%, 'L': 26.67%, 'K': 6.67%, 'M': 6.67%, 'F': 0%, 'P': 0%, 'S': 0%, 'T': 6.67%, 'W': 0%, 'Y': 0%, 'V': 0%

Missing Amino Acid(s)

C, D, E, F, N, P, Q, R, S, V, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

A, H, K, M, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1549.98 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	188.667	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	3.673	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	1.56	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.439	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.702	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.089	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.467, 0.2, 0.4 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.cereus (Gram-positive), E.cloacae (Gram-negative), E.faecalis (Gram-positive), L.innocua (Gram-positive), L.lactis (Gram-positive), M.luteus (Gram-negative), S.aureus (Gram-positive), S.epidermidis (Gram-positive), S.uberis (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Maselli VM, Brinkworth CS, Bowie JH, et al. Host-defence skin peptides of the Australian Common Froglet Crinia signifera: sequence determination using positive and negative ion electrospray mass spectra. Rapid Commun Mass Spectrom. 2004;18(18):2155-61. Published 2004. doi:10.1002/rcm.1602

PMID: 15317042

Citation 2: Maselli VM, Bilusich D, Bowie JH, et al. Host-defence skin peptides of the Australian Streambank Froglet Crinia riparia: isolation and sequence determination by positive and negative ion electrospray mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(5):797-803. Published 2006. doi:10.1002/rcm.2360

PMID: 16470724

Citation 3: Jackway RJ, Pukala TL, Maselli VM, et al. Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: structure, activity and evolutionary trends. Regul Pept. 2008;151(1-3):80-7. Published 2008 Nov 29. doi:10.1016/j.regpep.2008.06.004

PMID: 18601958

5.2 Protein Sequence Databases

UniProt: P86131

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P86131

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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