AMPDB_415 | L-amino acid oxidase

PEPTIDE SUMMARY

L-amino acid oxidase

1 General Description

AMPDB ID: AMPDB_415

Protein Names: L-amino acid oxidase (Bpic-LAAO) (LAO) (EC 1.4.3.2)

Protein Family: Flavin monoamine oxidase family; FIG1 subfamily

Gene Name: Nil

Source Organism: Bothrops pictus (Desert lancehead)

Protein Length: 498 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

SLLFLAAVGSCADDRNPLEECFRETDYEEFLEIAKNGLSTTSNPKRVVIVGAGMSGLSAAYVLANAGHQVTVLEASERAGGRVKTYRNEKEGWYANLGPMRLPEKHRIVREYIKKFDLRLNEFSQENENAWYFLQNIKKRVREVNKDPGVLEYPVKPSEVGKSAGQLYEESLRKAVEELRRTNCSYMLNKYDTYSTKEYLLKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGGMDKLPTSMYQAIQEKVHLNARVIEIQQDVKEVTVTYQTSQKETLSVTADYVIVCTTSRAARRITFEPPLPPKKAHALLSVHYRSGTKIFLTCTKKFWEDDGIHGGKSTTDLPSRFIYYPNHNFPNGVGVIIAYGIGDDANYFQALDFEDCGDIVINDLSLIHQLPKEEIQAICRPSMIQRWSLDNYAMGGITTFTPYHFQHFSEALTAPVDRIYFAGEYTAQAHGWIDSTIKSGLRAATDVNRASENK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 37, 'R': 27, 'N': 24, 'D': 28, 'C': 7, 'Q': 16, 'E': 40, 'G': 33, 'H': 12, 'I': 30, 'L': 40, 'K': 31, 'M': 8, 'F': 20, 'P': 20, 'S': 32, 'T': 29, 'W': 5, 'Y': 27, 'V': 32

Frequencies of Amino Acids

'A': 7.43%, 'R': 5.42%, 'N': 4.82%, 'D': 5.62%, 'C': 1.41%, 'Q': 3.21%, 'E': 8.03%, 'G': 6.63%, 'H': 2.41%, 'I': 6.02%, 'L': 8.03%, 'K': 6.22%, 'M': 1.61%, 'F': 4.02%, 'P': 4.02%, 'S': 6.43%, 'T': 5.82%, 'W': 1%, 'Y': 5.42%, 'V': 6.43%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

E, L

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

225

Hydrophilic Amino Acid(s) Count

273

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	56348.6 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	80.884	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	42.432	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.427	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.878	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.972	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-9.294	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.309, 0.219, 0.251 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.104	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	67730, 68105	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), E.faecalis (Gram-positive), P.aeruginosa (Gram-negative), S.aureus (Gram-positive), V.cholerae (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Oxidoreductase

4.4 Inhibitory Effect

Platelet aggregation inhibiting toxin

4.5 Other Biological Activity

Toxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Lazo F, Vivas-Ruiz DE, Sandoval GA, et al. Biochemical, biological and molecular characterization of an L-Amino acid oxidase (LAAO) purified from Bothrops pictus Peruvian snake venom. Toxicon. 2017;139:74-86. Published 2017 Dec 1. doi:10.1016/j.toxicon.2017.10.001

PMID: 29024770

5.2 Protein Sequence Databases

UniProt: X2L4E2

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: X2L4E2

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	KJ094993	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR002937, IPR036188, IPR001613

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

Download