AMPDB_414 | L-amino acid oxidase

PEPTIDE SUMMARY

L-amino acid oxidase

1 General Description

AMPDB ID: AMPDB_414

Protein Names: L-amino acid oxidase (CC-LAAO) (LAO) (EC 1.4.3.2)

Protein Family: Flavin monoamine oxidase family; FIG1 subfamily

Gene Name: Nil

Source Organism: Cerastes cerastes (Horned desert viper)

Protein Length: 516 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MNVFFMFSLLFLAALESCADDKNPLEEEFFEADYEEFLLIAKNGLQQTSNPKRVVIVGAGMSGLSAAYVLAKTGHEVILLEASERVGGRVSTYRNDQEGWYANLGPMRLPERHRIVREYIRKFGLQLNEFSQENENAWYFIKNIRKRVGEVNKDPGVLEYPVKPSEKGKSAPQLYRDSLQKIIEEYGRSNCSYILNKYDTYSTKDYLIKEGNLSPGAVDMVGDLLNEDSGYYVSFIESLKPDDIFAYENRFDEIVGGFDKLPTSMYQAIQEKVRLNVRVIKIQQDVKEVTVTYQTPAKNLSYVTADYVIVCTTSGAARRIKFEPPLPLKKAHALRSVHYRSGTKIFLTCTKKFWEDDGIHGGKSITDRPSRLIHYPNHNFPNGIGVLVIFTIADDADFFLALDNKTIADIVIHDLSLIHQLPKEKIRDLCYVSMIQKWSLDKYAMGGITTFTPYQFQHFSEALTAPVDRIYFAGEYTAQAHGWIDSTIKSGLTAARDVNRASENPSGIHLSNDNEL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 35, 'R': 26, 'N': 26, 'D': 32, 'C': 5, 'Q': 17, 'E': 35, 'G': 33, 'H': 12, 'I': 37, 'L': 45, 'K': 34, 'M': 8, 'F': 25, 'P': 22, 'S': 34, 'T': 25, 'W': 5, 'Y': 27, 'V': 33

Frequencies of Amino Acids

'A': 6.78%, 'R': 5.04%, 'N': 5.04%, 'D': 6.2%, 'C': 0.97%, 'Q': 3.29%, 'E': 6.78%, 'G': 6.4%, 'H': 2.33%, 'I': 7.17%, 'L': 8.72%, 'K': 6.59%, 'M': 1.55%, 'F': 4.84%, 'P': 4.26%, 'S': 6.59%, 'T': 4.84%, 'W': 0.97%, 'Y': 5.23%, 'V': 6.4%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, W

Hydrophobic Amino Acid(s) Count

243

Hydrophilic Amino Acid(s) Count

273

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	58556.5 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	87.306	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	36.515	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.327	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.942	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.388	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-6.178	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.333, 0.223, 0.238 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.11	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	67730, 67980	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Oxidoreductase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Toxin, Anti-cancer, Cytotoxin, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Abdelkafi-Koubaa Z, Jebali J, Othman H, et al. A thermoactive L-amino acid oxidase from Cerastes cerastes snake venom: purification, biochemical and molecular characterization. Toxicon. 2014;89:32-44. Published 2014 Oct. doi:10.1016/j.toxicon.2014.06.020

PMID: 25009089

Citation 2: Abdelkafi-Koubaa Z, Aissa I, Morjen M, et al. Interaction of a snake venom L-amino acid oxidase with different cell types membrane. Int J Biol Macromol. 2016;82:757-64. Published 2016 Jan. doi:10.1016/j.ijbiomac.2015.09.065

PMID: 26433175

5.2 Protein Sequence Databases

UniProt: X2JCV5

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: X2JCV5

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	KJ028110	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR002937, IPR036188, IPR001613

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: 1.4.3.2

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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