AMPDB_4136 | Defensin-1

PEPTIDE SUMMARY

Defensin-1

1 General Description

AMPDB ID: AMPDB_4136

Protein Names: Defensin-1 (PhD1) [Cleaved into: Defensin-2 (PhD2)]

Protein Family: Alpha-defensin family

Gene Name: Nil

Source Organism: Papio hamadryas (Hamadryas baboon)

Protein Length: 33 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

RRICRCRIGRCLGLEVYFGVCFLHGRLARRCCR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 9, 'N': 0, 'D': 0, 'C': 6, 'Q': 0, 'E': 1, 'G': 4, 'H': 1, 'I': 2, 'L': 4, 'K': 0, 'M': 0, 'F': 2, 'P': 0, 'S': 0, 'T': 0, 'W': 0, 'Y': 1, 'V': 2

Frequencies of Amino Acids

'A': 3.03%, 'R': 27.27%, 'N': 0%, 'D': 0%, 'C': 18.18%, 'Q': 0%, 'E': 3.03%, 'G': 12.12%, 'H': 3.03%, 'I': 6.06%, 'L': 12.12%, 'K': 0%, 'M': 0%, 'F': 6.06%, 'P': 0%, 'S': 0%, 'T': 0%, 'W': 0%, 'Y': 3.03%, 'V': 6.06%

Missing Amino Acid(s)

D, K, M, N, P, Q, S, T, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

A, E, H, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3942.83 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	91.515	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	44.821	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.148	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.799	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.833	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	7.718	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.333, 0.121, 0.182 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.091	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	1490, 1865	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), L.monocytogenes (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Fungicide, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Tsvetkova EV, Aleshina GM, Shamova OV, et al. alpha-Defensins from blood leukocytes of the monkey Papio hamadryas. Biochemistry (Mosc). 2006;71(8):879-83. Published 2006 Aug. doi:10.1134/s0006297906080098

PMID: 16978151

5.2 Protein Sequence Databases

UniProt: P84757

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P84757

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR006081

PANTHER: Not found

PROSITE: PS00269

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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