AMPDB_4133 | Dermaseptin-H7

PEPTIDE SUMMARY

Dermaseptin-H7

1 General Description

AMPDB ID: AMPDB_4133

Protein Names: Dermaseptin-H7 (DRS-H7) (DShypo 05)

Protein Family: Frog skin active peptide (FSAP) family; Dermaseptin subfamily

Gene Name: Nil

Source Organism: Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa hypochondrialis)

Protein Length: 29 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GLWSTIKQKGKEAAIAAAKAAGQAALGAL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 10, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 2, 'E': 1, 'G': 4, 'H': 0, 'I': 2, 'L': 3, 'K': 4, 'M': 0, 'F': 0, 'P': 0, 'S': 1, 'T': 1, 'W': 1, 'Y': 0, 'V': 0

Frequencies of Amino Acids

'A': 34.48%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 6.9%, 'E': 3.45%, 'G': 13.79%, 'H': 0%, 'I': 6.9%, 'L': 10.34%, 'K': 13.79%, 'M': 0%, 'F': 0%, 'P': 0%, 'S': 3.45%, 'T': 3.45%, 'W': 3.45%, 'Y': 0%, 'V': 0%

Missing Amino Acid(s)

C, D, F, H, M, N, P, R, V, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

E, S, T, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2795.28 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	101.724	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	14.276	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.286	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.452	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.803	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.999	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.207, 0.172, 0.483 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.034	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), L.amazonensis, S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide, Anti-protozoal, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Brand GD, Leite JR, de SÃ¡ Mandel SM, et al. Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia). Biochem Biophys Res Commun. 2006;347(3):739-46. Published 2006 Sep 1. doi:10.1016/j.bbrc.2006.06.168

PMID: 16844081

Citation 2: Amiche M, Ladram A, Nicolas P, et al. A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. Peptides. 2008;29(11):2074-82. Published 2008 Nov. doi:10.1016/j.peptides.2008.06.017

PMID: 18644413

5.2 Protein Sequence Databases

UniProt: P84600

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P84600

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR022731

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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