AMPDB_4126 | Phylloseptin-H1

PEPTIDE SUMMARY

Phylloseptin-H1

1 General Description

AMPDB ID: AMPDB_4126

Protein Names: Phylloseptin-H1 (PLS-H1) (Phylloseptin-1) (PS-1)

Protein Family: Frog skin active peptide (FSAP) family; Phylloseptin subfamily

Gene Name: psn1 psn-1

Source Organism: Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa hypochondrialis)

Protein Length: 19 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

FLSLIPHAINAVSAIAKHN

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 4, 'R': 0, 'N': 2, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 0, 'H': 2, 'I': 3, 'L': 2, 'K': 1, 'M': 0, 'F': 1, 'P': 1, 'S': 2, 'T': 0, 'W': 0, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 21.05%, 'R': 0%, 'N': 10.53%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 0%, 'H': 10.53%, 'I': 15.79%, 'L': 10.53%, 'K': 5.26%, 'M': 0%, 'F': 5.26%, 'P': 5.26%, 'S': 10.53%, 'T': 0%, 'W': 0%, 'Y': 0%, 'V': 5.26%

Missing Amino Acid(s)

C, D, E, G, M, Q, R, T, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

F, K, P, V

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2016.37 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	138.947	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	20.421	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.779	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.484	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.704	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.18	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.368, 0.263, 0.316 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.053	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), E.faecalis (Gram-positive), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Leite JR, Silva LP, Rodrigues MI, et al. Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus. Peptides. 2005;26(4):565-73. Published 2005 Apr. doi:10.1016/j.peptides.2004.11.002

PMID: 15752569

Citation 2: Amiche M, Ladram A, Nicolas P, et al. A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. Peptides. 2008;29(11):2074-82. Published 2008 Nov. doi:10.1016/j.peptides.2008.06.017

PMID: 18644413

Citation 3: Resende JM, Moraes CM, Prates MV, et al. Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations. Peptides. 2008;29(10):1633-44. Published 2008 Oct. doi:10.1016/j.peptides.2008.06.022

PMID: 18656510

5.2 Protein Sequence Databases

UniProt: P84566

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P84566

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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