AMPDB_4086 | Ruminococcin-A

PEPTIDE SUMMARY

Ruminococcin-A

1 General Description

AMPDB ID: AMPDB_4086

Protein Names: Ruminococcin-A

Protein Family: Type A lantibiotic family

Gene Name: rumA1; rumA2; rumA3

Source Organism: Blautia hansenii (Ruminococcus hansenii)

Protein Length: 47 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MRNDVLTLTNPMEENELEQILGGGNGVLKTISHECNMNTWQFLFTCC

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 0, 'R': 1, 'N': 6, 'D': 1, 'C': 3, 'Q': 2, 'E': 5, 'G': 4, 'H': 1, 'I': 2, 'L': 6, 'K': 1, 'M': 3, 'F': 2, 'P': 1, 'S': 1, 'T': 5, 'W': 1, 'Y': 0, 'V': 2

Frequencies of Amino Acids

'A': 0%, 'R': 2.13%, 'N': 12.77%, 'D': 2.13%, 'C': 6.38%, 'Q': 4.26%, 'E': 10.64%, 'G': 8.51%, 'H': 2.13%, 'I': 4.26%, 'L': 12.77%, 'K': 2.13%, 'M': 6.38%, 'F': 4.26%, 'P': 2.13%, 'S': 2.13%, 'T': 10.64%, 'W': 2.13%, 'Y': 0%, 'V': 4.26%

Missing Amino Acid(s)

A, Y

Most Occurring Amino Acid(s)

L, N

Less Occurring Amino Acid(s)

D, H, K, P, R, S, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	5346.1 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	78.723	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	21.706	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.213	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.487	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.132	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-4.088	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.277, 0.255, 0.298 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.064	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5625	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.longum (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Lantibiotic, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Marcille F, Gomez A, Joubert P, et al. Distribution of genes encoding the trypsin-dependent lantibiotic ruminococcin A among bacteria isolated from human fecal microbiota. Appl Environ Microbiol. 2002;68(7):3424-31. Published 2002 Jul. doi:10.1128/AEM.68.7.3424-3431.2002

PMID: 12089024

5.2 Protein Sequence Databases

UniProt: P83675

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P83675

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AF439552	GenBank \|\| EMBL
2.	AF439552	GenBank \|\| EMBL
3.	AF439552	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR007682

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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