AMPDB_406 | Crotamine

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7519.05 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	58.615	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	61.891	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.294	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.464	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.962	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	8.807	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.292, 0.231, 0.215 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.154	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	13980, 14355	Computed by ProtParam module (biopython 1.79)

Citation 1: RÃ¡dis-Baptista G, Oguiura N, Hayashi MA, et al. Nucleotide sequence of crotamine isoform precursors from a single South American rattlesnake (Crotalus durissus terrificus). Toxicon. 1999;37(7):973-84. Published 1999 Jul. doi:10.1016/s0041-0101(98)00226-8

PMID: 10484745

Citation 2: RÃ¡dis-Baptista G, Kubo T, Oguiura N, et al. Structure and chromosomal localization of the gene for crotamine, a toxin from the South American rattlesnake, Crotalus durissus terrificus. Toxicon. 2003;42(7):747-52. Published 2003 Dec. doi:10.1016/j.toxicon.2003.10.019

PMID: 14757205

Citation 3: Laure CJ, Laure CJ. [The primary structure of crotamine (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975;356(2):213-5. Published 1975 Feb. doi:

PMID: 1176086

Citation 4: Peigneur S, Orts DJ, Prieto da Silva AR, et al. Crotamine pharmacology revisited: novel insights based on the inhibition of KV channels. Mol Pharmacol. 2012;82(1):90-6. Published 2012 Jul. doi:10.1124/mol.112.078188

PMID: 22498659

Citation 5: Chang CC, Tseng KH, Tseng KH. Effect of crotamine, a toxin of South American rattlesnake venom, on the sodium channel of murine skeletal muscle. Br J Pharmacol. 1978;63(3):551-9. Published 1978 Jul. doi:10.1111/j.1476-5381.1978.tb07811.x

PMID: 667499

Citation 6: Mancin AC, Soares AM, AndriÃ£o-Escarso SH, et al. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. Toxicon. 1998;36(12):1927-37. Published 1998 Dec. doi:10.1016/s0041-0101(98)00117-2

PMID: 9839677

Citation 7: Kerkis A, Kerkis I, RÃ¡dis-Baptista G, et al. Crotamine is a novel cell-penetrating protein from the venom of rattlesnake Crotalus durissus terrificus. FASEB J. 2004;18(12):1407-9. Published 2004 Sep. doi:10.1096/fj.03-1459fje

PMID: 15231729

Citation 8: Nascimento FD, Hayashi MA, Kerkis A, et al. Crotamine mediates gene delivery into cells through the binding to heparan sulfate proteoglycans. J Biol Chem. 2007;282(29):21349-60. Published 2007 Jul 20. doi:10.1074/jbc.M604876200

PMID: 17491023

Citation 9: Rizzi CT, Carvalho-de-Souza JL, Schiavon E, et al. Crotamine inhibits preferentially fast-twitching muscles but is inactive on sodium channels. Toxicon. 2007;50(4):553-62. Published 2007 Sep 15. doi:10.1016/j.toxicon.2007.04.026

PMID: 17588630

Citation 10: Hayashi MA, Nascimento FD, Kerkis A, et al. Cytotoxic effects of crotamine are mediated through lysosomal membrane permeabilization. Toxicon. 2008;52(3):508-17. Published 2008 Sep 1. doi:10.1016/j.toxicon.2008.06.029

PMID: 18662711

Citation 11: Yount NY, Kupferwasser D, Spisni A, et al. Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine. Proc Natl Acad Sci U S A. 2009;106(35):14972-7. Published 2009 Sep 1. doi:10.1073/pnas.0904465106

PMID: 19706485

Citation 12: Pereira A, Kerkis A, Hayashi MA, et al. Crotamine toxicity and efficacy in mouse models of melanoma. Expert Opin Investig Drugs. 2011;20(9):1189-200. Published 2011 Sep. doi:10.1517/13543784.2011.602064

PMID: 21834748

Citation 13: Oguiura N, Boni-Mitake M, Affonso R, et al. In vitro antibacterial and hemolytic activities of crotamine, a small basic myotoxin from rattlesnake Crotalus durissus. J Antibiot (Tokyo). 2011;64(4):327-31. Published 2011 Apr. doi:10.1038/ja.2011.10

PMID: 21386851

Citation 14: Nascimento FD, Sancey L, Pereira A, et al. The natural cell-penetrating peptide crotamine targets tumor tissue in vivo and triggers a lethal calcium-dependent pathway in cultured cells. Mol Pharm. 2012;9(2):211-21. Published 2012 Feb 6. doi:10.1021/mp2000605

PMID: 22142367

Citation 15: Yamane ES, Bizerra FC, Oliveira EB, et al. Unraveling the antifungal activity of a South American rattlesnake toxin crotamine. Biochimie. 2013;95(2):231-40. Published 2013 Feb. doi:10.1016/j.biochi.2012.09.019

PMID: 23022146

Citation 16: Kerkis I, Silva Fde S, Pereira A, et al. Biological versatility of crotamine--a cationic peptide from the venom of a South American rattlesnake. Expert Opin Investig Drugs. 2010;19(12):1515-25. Published 2010 Dec. doi:10.1517/13543784.2010.534457

PMID: 21062230

Citation 17: Nicastro G, Franzoni L, de Chiara C, et al. Solution structure of crotamine, a Na+ channel affecting toxin from Crotalus durissus terrificus venom. Eur J Biochem. 2003;270(9):1969-79. Published 2003 May. doi:10.1046/j.1432-1033.2003.03563.x

PMID: 12709056

Citation 18: Fadel V, Bettendorff P, Herrmann T, et al. Automated NMR structure determination and disulfide bond identification of the myotoxin crotamine from Crotalus durissus terrificus. Toxicon. 2005;46(7):759-67. Published 2005 Dec 1. doi:10.1016/j.toxicon.2005.07.018

PMID: 16185738

Sl. no.	Accession(s)	Access Link(s)
1.	AF053075	GenBank \|\| EMBL
2.	AF223946	GenBank \|\| EMBL
3.	AF223947	GenBank \|\| EMBL

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