AMPDB_4045 | Brevinin-1Sc

PEPTIDE SUMMARY

Brevinin-1Sc

1 General Description

AMPDB ID: AMPDB_4045

Protein Names: Brevinin-1Sc

Protein Family: Frog skin active peptide (FSAP) family; Brevinin subfamily

Gene Name: Nil

Source Organism: Lithobates sphenocephalus (Southern leopard frog) (Rana sphenocephala)

Protein Length: 24 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

FFPIVAGVAGQVLKKIYCTISKKC

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 0, 'N': 0, 'D': 0, 'C': 2, 'Q': 1, 'E': 0, 'G': 2, 'H': 0, 'I': 3, 'L': 1, 'K': 4, 'M': 0, 'F': 2, 'P': 1, 'S': 1, 'T': 1, 'W': 0, 'Y': 1, 'V': 3

Frequencies of Amino Acids

'A': 8.33%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 8.33%, 'Q': 4.17%, 'E': 0%, 'G': 8.33%, 'H': 0%, 'I': 12.5%, 'L': 4.17%, 'K': 16.67%, 'M': 0%, 'F': 8.33%, 'P': 4.17%, 'S': 4.17%, 'T': 4.17%, 'W': 0%, 'Y': 4.17%, 'V': 12.5%

Missing Amino Acid(s)

D, E, H, M, N, R, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

L, P, Q, S, T, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2614.25 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	109.583	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	17.438	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.825	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.63	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.057	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.872	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.417, 0.167, 0.125 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.125	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	1490, 1615	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Conlon JM, Halverson T, Dulka J, et al. Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala. J Pept Res. 1999;54(6):522-7. Published 1999 Dec. doi:10.1034/j.1399-3011.1999.00123.x

PMID: 10604597

5.2 Protein Sequence Databases

UniProt: P82906

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P82906

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR012520

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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