AMPDB_4037 | Ranatuerin-2Cb

PEPTIDE SUMMARY

Ranatuerin-2Cb

1 General Description

AMPDB ID: AMPDB_4037

Protein Names: Ranatuerin-2Cb

Protein Family: Frog skin active peptide (FSAP) family; Ranatuerin subfamily

Gene Name: Nil

Source Organism: Lithobates clamitans (Green frog) (Rana clamitans)

Protein Length: 27 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GLFLDTLKGLAGKLLQGLKCIKAGCKP

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 0, 'N': 0, 'D': 1, 'C': 2, 'Q': 1, 'E': 0, 'G': 5, 'H': 0, 'I': 1, 'L': 7, 'K': 5, 'M': 0, 'F': 1, 'P': 1, 'S': 0, 'T': 1, 'W': 0, 'Y': 0, 'V': 0

Frequencies of Amino Acids

'A': 7.41%, 'R': 0%, 'N': 0%, 'D': 3.7%, 'C': 7.41%, 'Q': 3.7%, 'E': 0%, 'G': 18.52%, 'H': 0%, 'I': 3.7%, 'L': 25.93%, 'K': 18.52%, 'M': 0%, 'F': 3.7%, 'P': 3.7%, 'S': 0%, 'T': 3.7%, 'W': 0%, 'Y': 0%, 'V': 0%

Missing Amino Acid(s)

E, H, M, N, R, S, V, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

D, F, I, P, Q, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2786.47 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	122.963	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	-5.522	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.433	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.557	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.23	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.873	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.333, 0.222, 0.333 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.037	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 125	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

C.albicans, E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Halverson T, Basir YJ, Knoop FC, et al. Purification and characterization of antimicrobial peptides from the skin of the North American green frog Rana clamitans. Peptides. 2000;21(4):469-76. Published 2000 Apr. doi:10.1016/s0196-9781(00)00178-9

PMID: 10822101

5.2 Protein Sequence Databases

UniProt: P82879

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P82879

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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