AMPDB_400 | Cystatin-11

PEPTIDE SUMMARY

Cystatin-11

1 General Description

AMPDB ID: AMPDB_400

Protein Names: Cystatin-11

Protein Family: Cystatin family

Gene Name: CST11 CST8L

Source Organism: Homo sapiens (Human)

Protein Length: 138 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MMAEPWQALQLLLAILLTLMALPYQARKKTFLSVHEVMAVENYAKDSLQWITDQYNKESDDKYHFRIFRVLKVQRQVTDHLEYHLNVEMQWTTCQKPETTNCVPQERELHKQVNCFFSVFAVPWFEQYKILNKSCSSD

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 8, 'R': 5, 'N': 6, 'D': 6, 'C': 4, 'Q': 12, 'E': 10, 'G': 0, 'H': 5, 'I': 4, 'L': 15, 'K': 10, 'M': 5, 'F': 7, 'P': 5, 'S': 7, 'T': 8, 'W': 4, 'Y': 6, 'V': 11

Frequencies of Amino Acids

'A': 5.8%, 'R': 3.62%, 'N': 4.35%, 'D': 4.35%, 'C': 2.9%, 'Q': 8.7%, 'E': 7.25%, 'G': 0%, 'H': 3.62%, 'I': 2.9%, 'L': 10.87%, 'K': 7.25%, 'M': 3.62%, 'F': 5.07%, 'P': 3.62%, 'S': 5.07%, 'T': 5.8%, 'W': 2.9%, 'Y': 4.35%, 'V': 7.97%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, I, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	16506 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	82.609	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	38.942	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.38	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.704	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	7.027	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-0.783	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.341, 0.13, 0.275 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.123	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	30940, 31190	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Protease inhibitor, Thiol protease inhibitor

4.5 Other Biological Activity

Enzyme inhibitor, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Hamil KG, Liu Q, Sivashanmugam P, et al. Cystatin 11: a new member of the cystatin type 2 family. Endocrinology. 2002;143(7):2787-96. Published 2002 Jul. doi:10.1210/endo.143.7.8925

PMID: 12072414

Citation 2: Deloukas P, Matthews LH, Ashurst J, et al. The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001;414(6866):865-71. Published 2001 Dec 20-27. doi:10.1038/414865a

PMID: 11780052

Citation 3: Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004;14(10B):2121-7. Published 2004 Oct. doi:10.1101/gr.2596504

PMID: 15489334

5.2 Protein Sequence Databases

UniProt: Q9H112

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q9H112

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AF335480	GenBank \|\| EMBL
2.	AF335481	GenBank \|\| EMBL
3.	AL096677	GenBank \|\| EMBL
4.	CH471133	GenBank \|\| EMBL
5.	BC121079	GenBank \|\| EMBL
6.	BC121080	GenBank \|\| EMBL