AMPDB_3949 | Antimicrobial protein PN-AMP1

PEPTIDE SUMMARY

Antimicrobial protein PN-AMP1

1 General Description

AMPDB ID: AMPDB_3949

Protein Names: Antimicrobial protein PN-AMP1 [Cleaved into: Antimicrobial protein PN-AMP2]

Protein Family: Nil

Gene Name: Nil

Source Organism: Ipomoea nil (Japanese morning glory) (Pharbitis nil)

Protein Length: 41 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

QQCGRQASGRLCGNRLCCSQWGYCGSTASYCGAGCQSQCRS

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 3, 'R': 4, 'N': 1, 'D': 0, 'C': 8, 'Q': 6, 'E': 0, 'G': 7, 'H': 0, 'I': 0, 'L': 2, 'K': 0, 'M': 0, 'F': 0, 'P': 0, 'S': 6, 'T': 1, 'W': 1, 'Y': 2, 'V': 0

Frequencies of Amino Acids

'A': 7.32%, 'R': 9.76%, 'N': 2.44%, 'D': 0%, 'C': 19.51%, 'Q': 14.63%, 'E': 0%, 'G': 17.07%, 'H': 0%, 'I': 0%, 'L': 4.88%, 'K': 0%, 'M': 0%, 'F': 0%, 'P': 0%, 'S': 14.63%, 'T': 2.44%, 'W': 2.44%, 'Y': 4.88%, 'V': 0%

Missing Amino Acid(s)

D, E, F, H, I, K, M, P, V

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

N, T, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	4325.82 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	26.342	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	35.722	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.52	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.427	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.406	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.5	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.122, 0.341, 0.122 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.073	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	8480, 8980	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Plant defense, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Koo JC, Lee SY, Chun HJ, et al. Two hevein homologs isolated from the seed of Pharbitis nil L. exhibit potent antifungal activity. Biochim Biophys Acta. 1998;1382(1):80-90. Published 1998 Jan 15. doi:10.1016/s0167-4838(97)00148-9

PMID: 9507071

5.2 Protein Sequence Databases

UniProt: P81591

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P81591

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001002, IPR018371, IPR036861

PANTHER: Not found

PROSITE: PS00026, PS50941

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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