AMPDB_3941 | Neutrophil defensin 4

PEPTIDE SUMMARY

Neutrophil defensin 4

1 General Description

AMPDB ID: AMPDB_3941

Protein Names: Neutrophil defensin 4 (HANP-4)

Protein Family: Alpha-defensin family

Gene Name: Nil

Source Organism: Mesocricetus auratus (Golden hamster)

Protein Length: 33 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

VTCFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 0, 'R': 4, 'N': 1, 'D': 1, 'C': 6, 'Q': 2, 'E': 1, 'G': 3, 'H': 0, 'I': 1, 'L': 2, 'K': 1, 'M': 0, 'F': 2, 'P': 1, 'S': 1, 'T': 3, 'W': 0, 'Y': 2, 'V': 2

Frequencies of Amino Acids

'A': 0%, 'R': 12.12%, 'N': 3.03%, 'D': 3.03%, 'C': 18.18%, 'Q': 6.06%, 'E': 3.03%, 'G': 9.09%, 'H': 0%, 'I': 3.03%, 'L': 6.06%, 'K': 3.03%, 'M': 0%, 'F': 6.06%, 'P': 3.03%, 'S': 3.03%, 'T': 9.09%, 'W': 0%, 'Y': 6.06%, 'V': 6.06%

Missing Amino Acid(s)

A, H, M, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

D, E, I, K, N, P, S

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3821.46 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	53.03	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	42.391	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.2	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.733	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.379	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.626	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.273, 0.182, 0.091 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.121	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	2980, 3355	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Fungicide, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Mak P, WÃ³jcik K, Thogersen IB, et al. Isolation, antimicrobial activities, and primary structures of hamster neutrophil defensins. Infect Immun. 1996;64(11):4444-9. Published 1996 Nov. doi:10.1128/iai.64.11.4444-4449.1996

PMID: 8890190

5.2 Protein Sequence Databases

UniProt: P81468

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P81468

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR006081

PANTHER: Not found

PROSITE: PS00269

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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