AMPDB_3916 | Antimicrobial peptide THP2

PEPTIDE SUMMARY

Antimicrobial peptide THP2

1 General Description

AMPDB ID: AMPDB_3916

Protein Names: Antimicrobial peptide THP2 (Turkey heterophil peptide 2)

Protein Family: Beta-defensin family

Gene Name: Nil

Source Organism: Meleagris gallopavo (Wild turkey)

Protein Length: 64 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MRILYLLFSLLFLALQVSPGLSSPKRDMLFCKRGTCHFGRCPSHLIKVGSCFGFRSCCKWPWDA

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 5, 'N': 0, 'D': 2, 'C': 6, 'Q': 1, 'E': 0, 'G': 5, 'H': 2, 'I': 2, 'L': 10, 'K': 4, 'M': 2, 'F': 6, 'P': 4, 'S': 7, 'T': 1, 'W': 2, 'Y': 1, 'V': 2

Frequencies of Amino Acids

'A': 3.13%, 'R': 7.81%, 'N': 0%, 'D': 3.13%, 'C': 9.38%, 'Q': 1.56%, 'E': 0%, 'G': 7.81%, 'H': 3.13%, 'I': 3.13%, 'L': 15.63%, 'K': 6.25%, 'M': 3.13%, 'F': 9.38%, 'P': 6.25%, 'S': 10.94%, 'T': 1.56%, 'W': 3.13%, 'Y': 1.56%, 'V': 3.13%

Missing Amino Acid(s)

E, N

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Q, T, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7326.83 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	85.313	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	61.981	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.341	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.673	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.624	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	6.807	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.359, 0.25, 0.219 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.141	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	12490, 12865	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), Staphylococcus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Brockus CW, Jackwood MW, Harmon BG, et al. Characterization of beta-defensin prepropeptide mRNA from chicken and turkey bone marrow. Anim Genet. 1998;29(4):283-9. Published 1998 Aug. doi:10.1046/j.1365-2052.1998.00338.x

PMID: 9745666

Citation 2: Evans EW, Beach GG, Wunderlich J, et al. Isolation of antimicrobial peptides from avian heterophils. J Leukoc Biol. 1994;56(5):661-5. Published 1994 Nov. doi:10.1002/jlb.56.5.661

PMID: 7964174

Citation 3: Kannan L, Rath NC, Liyanage R, et al. Direct screening identifies mature beta-defensin 2 in avian heterophils. Poult Sci. 2009;88(2):372-9. Published 2009 Feb. doi:10.3382/ps.2008-00366

PMID: 19151352

5.2 Protein Sequence Databases

UniProt: P80392

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P80392

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AF033338	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001855

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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