AMPDB_39010 | Type VI secretion system tube protein Hcp

PEPTIDE SUMMARY

Type VI secretion system tube protein Hcp

1 General Description

AMPDB ID: AMPDB_39010

Protein Names: Type VI secretion system tube protein Hcp

Protein Family: Colicin pyosin nuclease family

Gene Name: hcp EWT59_11505 WLH_04160

Source Organism: Escherichia coli O25b:H4

Protein Length: 593 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MGDIVYLRIIGEKQGDISSGCGTYASVGNRWQVGHEDEIFAFALTNAITSTGNGVNLQGLQFCKLIDKSSPLLSNAINQNERLFIEIDLYRINKSGRWERYYYIQLRNASLTAIHVNISDNNLPTECVTVDYDYILCKHLIANTEFDWLAFPAGYNSLFIPPKSPPASNLKPEPLPVVNLPLSSPAVNPVYAKSCLKVKGCTDAGTAEEPAENFGQVAIFVQPVVDDCCGYHHPEANVIGEPAEAQTMLLFPSSVLATQIWGKWSLSGVLSATRGSYIGALASALYIPSAGEGSARVPGRDEFWYEEELRQKALAGSTATTRVRFFWGTDIHGKPQVYGVHTGEGTPYENVRVANMQWNEQTQRYEFTPAHDVDGPLITWTPENPEHGNVPGHTGNDRPPLEQPTILVTPIPDGTDTYTTPPFPVPDPKEFNDYILVFPAGSGIKPIYVYLKEDPRKLPGVVTGHGVPLSPGTRWLDMSVSNNGNGAPIPAHIVDKLRGREFKTFDEFREALWLEVSQEPELIAQFSEINQLRISQGFTPFAPDEGHYIGPKETLKKFQIHHFIAIEYGGGVYDIDNLRIVTPRLHDEIHYRR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 39, 'R': 26, 'N': 31, 'D': 29, 'C': 8, 'Q': 21, 'E': 40, 'G': 50, 'H': 17, 'I': 41, 'L': 46, 'K': 22, 'M': 4, 'F': 25, 'P': 50, 'S': 33, 'T': 36, 'W': 11, 'Y': 25, 'V': 39

Frequencies of Amino Acids

'A': 6.58%, 'R': 4.38%, 'N': 5.23%, 'D': 4.89%, 'C': 1.35%, 'Q': 3.54%, 'E': 6.75%, 'G': 8.43%, 'H': 2.87%, 'I': 6.91%, 'L': 7.76%, 'K': 3.71%, 'M': 0.67%, 'F': 4.22%, 'P': 8.43%, 'S': 5.56%, 'T': 6.07%, 'W': 1.85%, 'Y': 4.22%, 'V': 6.58%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

G, P

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

305

Hydrophilic Amino Acid(s) Count

288

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	65822.2 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	82.867	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	40.136	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.31	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.558	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.16	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-19.896	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.315, 0.277, 0.218 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.103	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	97750, 98250	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

No PMID found

5.2 Protein Sequence Databases

UniProt: A0A192CI92

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A192CI92

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	CP015085	GenBank \|\| EMBL
2.	SEWA01000004	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_000502513.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR037146, IPR036624, IPR044925, IPR003615, IPR016128, IPR036302, IPR008514

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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