AMPDB_3856 | Androctonin

PEPTIDE SUMMARY

Androctonin

1 General Description

AMPDB ID: AMPDB_3856

Protein Names: Androctonin

Protein Family: Nil

Gene Name: Nil

Source Organism: Androctonus australis (Sahara scorpion)

Protein Length: 25 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

RSVCRQIKICRRRGGCYYKCTNRPY

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 0, 'R': 6, 'N': 1, 'D': 0, 'C': 4, 'Q': 1, 'E': 0, 'G': 2, 'H': 0, 'I': 2, 'L': 0, 'K': 2, 'M': 0, 'F': 0, 'P': 1, 'S': 1, 'T': 1, 'W': 0, 'Y': 3, 'V': 1

Frequencies of Amino Acids

'A': 0%, 'R': 24%, 'N': 4%, 'D': 0%, 'C': 16%, 'Q': 4%, 'E': 0%, 'G': 8%, 'H': 0%, 'I': 8%, 'L': 0%, 'K': 8%, 'M': 0%, 'F': 0%, 'P': 4%, 'S': 4%, 'T': 4%, 'W': 0%, 'Y': 12%, 'V': 4%

Missing Amino Acid(s)

A, D, E, F, H, L, M, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

N, P, Q, S, T, V

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3080.66 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	42.8	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	95.12	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-1.056	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.659	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.567	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	7.747	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.24, 0.2, 0 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.12	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	4470, 4720	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Ehret-Sabatier L, Loew D, Goyffon M, et al. Characterization of novel cysteine-rich antimicrobial peptides from scorpion blood. J Biol Chem. 1996;271(47):29537-44. Published 1996 Nov 22. doi:10.1074/jbc.271.47.29537

PMID: 8939880

Citation 2: Hetru C, Letellier L, Oren Z, et al. Androctonin, a hydrophilic disulphide-bridged non-haemolytic anti-microbial peptide: a plausible mode of action. Biochem J. 2000;345 Pt 3(Pt 3):653-64. Published 2000 Feb 1. doi:

PMID: 10642525

Citation 3: Mandard N, Sy D, Maufrais C, et al. Androctonin, a novel antimicrobial peptide from scorpion Androctonus australis: solution structure and molecular dynamics simulations in the presence of a lipid monolayer. J Biomol Struct Dyn. 1999;17(2):367-80. Published 1999 Oct. doi:10.1080/07391102.1999.10508368

PMID: 10563585

5.2 Protein Sequence Databases

UniProt: P56684

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P56684

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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