AMPDB_3829 | Antibacterial peptide PMAP-23
PEPTIDE SUMMARY
Antibacterial peptide PMAP-23
1 General Description
AMPDB ID: AMPDB_3829
Protein Names: Antibacterial peptide PMAP-23 (Myeloid antibacterial peptide 23)
Protein Family: Cathelicidin family
Gene Name: PMAP23
Source Organism: Sus scrofa (Pig)
Protein Length: 153 AA
Protein Existence: Evidence at transcript level
2 Protein Sequence & Composition
2.1 Sequence
METQRASLCLGRWSLWLLLLGLVVPSASAQALSYREAVLRAVDRLNEQSSEANLYRLLELDQPPKADEDPGTPKPVSFTVKETVCPRPTRQPPELCDFKENGRVKQCVGTVTLKEIRGNFDITCNQLQSVRIIDLLWRVRRPQKPKFVTVWVR
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 8, 'R': 15, 'N': 5, 'D': 7, 'C': 5, 'Q': 9, 'E': 10, 'G': 6, 'H': 0, 'I': 4, 'L': 20, 'K': 8, 'M': 1, 'F': 4, 'P': 12, 'S': 9, 'T': 9, 'W': 4, 'Y': 2, 'V': 15
Frequencies of Amino Acids
'A': 5.23%, 'R': 9.8%, 'N': 3.27%, 'D': 4.58%, 'C': 3.27%, 'Q': 5.88%, 'E': 6.54%, 'G': 3.92%, 'H': 0%, 'I': 2.61%, 'L': 13.07%, 'K': 5.23%, 'M': 0.65%, 'F': 2.61%, 'P': 7.84%, 'S': 5.88%, 'T': 5.88%, 'W': 2.61%, 'Y': 1.31%, 'V': 9.8%
Missing Amino Acid(s)
H
Most Occurring Amino Acid(s)
L
Less Occurring Amino Acid(s)
M
Hydrophobic Amino Acid(s) Count
74
Hydrophilic Amino Acid(s) Count
79
Basic Amino Acid(s) Count
17
Acidic Amino Acid(s) Count
23
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 17486.3 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 94.837 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 41.365 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.337 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.775 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 9.416 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 5.705 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.32, 0.209, 0.255 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.065 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 24980, 25230 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
Gram Positive Bacteria
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Zanetti M, Storici P, Tossi A, et al. Molecular cloning and chemical synthesis of a novel antibacterial peptide derived from pig myeloid cells. J Biol Chem. 1994;269(11):7855-8. Published 1994 Mar 18. doi:
PMID: 8132502
5.2 Protein Sequence Databases
UniProt: P49930
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P49930
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. L26053 GenBank || EMBL
2. Y16624 GenBank || EMBL
CCDS: Not found
5.5 Protein-Protein Interaction Databases
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
PANTHER: PTHR10206
PROSITE: PS00946, PS00947
5.8 Genome Annotation Databases
Ensembl: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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