AMPDB_37892 | Putative klebicin D activity protein

PEPTIDE SUMMARY

Putative klebicin D activity protein

1 General Description

AMPDB ID: AMPDB_37892

Protein Names: Putative klebicin D activity protein

Protein Family: Colicin pyosin nuclease family

Gene Name: EAE_22400

Source Organism: Klebsiella aerogenes (strain ATCC 13048 DSM 30053 CCUG 1429 JCM 1235 KCTC 2190 NBRC 13534 NCIMB 10102 NCTC 10006 CDC 819-56) (Enterobacter aerogenes)

Protein Length: 692 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MSTELKGPGEIAGENLGGSGANLNERPDNSTPGGGSNGTGGNDSGGSSSGYTAARRQIDAVVNDPAVKSKLSAIIKGAKAINPNAHLSITELTETGTLKLGITDISADQASALGLGNIITVHANNGFMYTGGSIETGHVLGKTPPGIGGTGGSNDSGTIAAQNKVSPDIYLSVLQGTIPNGFWLSNDKVMTRVRVAYIINGGGKGDDRTGYRDKDVEVPSLTDAWNTSKQIKADIEEAARQAEAARKAEEARKAEEARKAEEARKAEEARKAEEARKAEEARKAEEARQALYKKAGILPTPSYSPEKAAAGSAALAKAGVMALNRAPAALQLTSVAGGVMTTASELAGWVASALWRGAVAVSDIAVVSPVGAMVGAFVAGFTPIPVGTGSDRVPGRDIEMLAVQARLMAAGKVSIEPGMTSVNLPVRSFITTDDDGRQSVHMVKTGVGGVSAAVPVLNAVRDEATGLDRITVPAVAGAPSRTILINPVPSGPTVPANTGNTGPVPKTPVHTGTDIRQADSIVTTTYPAAEDLAIQDFIYWQPDALVSGVEPIYVMLASPRDLPGKVTGKGEQVGDGWLDKAGEELGSPIPSQIADKLRGREFSNFNSFRRAFWKTVSDTPELSEQFDQASLGSIKLGKSSFVRKSERVGGRLKHELHHVKAIKDGGDVFDVDNLRVMTPKKHIEVHKSNGGK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 85, 'R': 36, 'N': 28, 'D': 38, 'C': 0, 'Q': 17, 'E': 41, 'G': 80, 'H': 10, 'I': 38, 'L': 42, 'K': 42, 'M': 12, 'F': 13, 'P': 39, 'S': 52, 'T': 46, 'W': 7, 'Y': 10, 'V': 56

Frequencies of Amino Acids

'A': 12.28%, 'R': 5.2%, 'N': 4.05%, 'D': 5.49%, 'C': 0%, 'Q': 2.46%, 'E': 5.92%, 'G': 11.56%, 'H': 1.45%, 'I': 5.49%, 'L': 6.07%, 'K': 6.07%, 'M': 1.73%, 'F': 1.88%, 'P': 5.64%, 'S': 7.51%, 'T': 6.65%, 'W': 1.01%, 'Y': 1.45%, 'V': 8.09%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

372

Hydrophilic Amino Acid(s) Count

320

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	72035.1 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	80.838	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	35.458	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.291	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.809	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	7.422	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-0.024	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.24, 0.288, 0.26 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.043	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	53400, 53400	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Shin SH, Kim S, Kim JY, et al. Complete genome sequence of Enterobacter aerogenes KCTC 2190. J Bacteriol. 2012;194(9):2373-4. Published 2012 May. doi:10.1128/JB.00028-12

PMID: 22493190

5.2 Protein Sequence Databases

UniProt: A0A0H3G2H6

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A0H3G2H6

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	CP002824	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_015705899.1, YP_004594658.1

5.5 Protein-Protein Interaction Databases

STRING: 1028307.EAE_22400

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR037146, IPR044925, IPR003615, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: eae:EAE_22400

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

Download