AMPDB_37889 | Putative colicin

PEPTIDE SUMMARY

Putative colicin

1 General Description

AMPDB ID: AMPDB_37889

Protein Names: Putative colicin

Protein Family: Colicin pyosin nuclease family

Gene Name: NRG857_00565

Source Organism: Escherichia coli O83:H1 (strain NRG 857C AIEC)

Protein Length: 593 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MGDIVYLRIIGEKQGDISSGCGTYASVGNRWQVGHEDEIFAFALTNAITSTGNGVNLQGLQFCKLIDKSSPLLSNAINQNERLFIEIDLYRINKSGRWERYYYIQLRNASLTAIHVNISDNNLLTECVTVDYDYILCKHLIANTEFDWLAFPAGYNSLFIPPKSPPASNLKPEPLPVVNLPLSSPAVNPVYAKSCLKVKGCTDAGTAEEPAENFGQVAIFAQPVVDDCCGYHHPEANVIGEPAEAQTMLLFPSSVLATQIWGKWSLSGVLSATRGSYIGALASALYIPSAGEGSARVPGRDEFWYEEELRQKALAGSTATTRVRFFWGTDIHSKPQVYGVHTGEGTPYENVRVANMLWNEERQRYEFTPAHDVDGPLITWTPENPEHGNVPGHTGNDRPPLDQPTILVTPIPDGTDTYTTPPFPVPDPKEFNDYILVFPAGSGIKPIYVYLKEDPRKLPGVVTGHGVPLSPGTRWLDMSVSNNGNGAPIPAHIADKLRGREFKTFDEFREALWLEVSKDSVLLAQFIKSNQNNVSQGYSPYVPEEGYYYGPNEIVKKFQIHHVVAIEHGGGVYDIDNFRIVTPRLHDEIHYRR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 40, 'R': 26, 'N': 34, 'D': 30, 'C': 8, 'Q': 18, 'E': 38, 'G': 49, 'H': 17, 'I': 38, 'L': 46, 'K': 23, 'M': 4, 'F': 23, 'P': 48, 'S': 36, 'T': 33, 'W': 11, 'Y': 28, 'V': 43

Frequencies of Amino Acids

'A': 6.75%, 'R': 4.38%, 'N': 5.73%, 'D': 5.06%, 'C': 1.35%, 'Q': 3.04%, 'E': 6.41%, 'G': 8.26%, 'H': 2.87%, 'I': 6.41%, 'L': 7.76%, 'K': 3.88%, 'M': 0.67%, 'F': 3.88%, 'P': 8.09%, 'S': 6.07%, 'T': 5.56%, 'W': 1.85%, 'Y': 4.72%, 'V': 7.25%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

302

Hydrophilic Amino Acid(s) Count

291

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	65795.1 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	83.019	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	39.547	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.312	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.578	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.343	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-17.902	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.319, 0.282, 0.216 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.105	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	102220, 102720	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Nash JH, Villegas A, Kropinski AM, et al. Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes. BMC Genomics. 2010;11:667. Published 2010 Nov 25. doi:10.1186/1471-2164-11-667

PMID: 21108814

5.2 Protein Sequence Databases

UniProt: A0A0H3EDB9

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A0H3EDB9

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	CP001855	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_000502511.1, YP_006118478.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR037146, IPR036624, IPR044925, IPR003615, IPR016128, IPR036302, IPR008514

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: eln:NRG857_00565

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

Download