AMPDB_37860 | Colicin E2

PEPTIDE SUMMARY

Colicin E2

1 General Description

AMPDB ID: AMPDB_37860

Protein Names: Colicin E2

Protein Family: Colicin pyosin nuclease family

Gene Name: Nil

Source Organism: Shigella sonnei

Protein Length: 571 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGHGNGGGNSNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPAVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFDRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEMSDADAALSAAQERRKQKENKEKDAKDKLDKESKRNKPGKATGKGKPVGDKWLDDAGKDSGAPIPDRIADKLRDKEFKNFDDFRKKFWEEVSKDPDLSKQFKGSNKTNIQKGKAPFARKKDQVGGRERFELHHDKPISQDGGVYDMNNIRVTTPKRHIDIHRGK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 63, 'R': 31, 'N': 36, 'D': 48, 'C': 0, 'Q': 24, 'E': 25, 'G': 62, 'H': 11, 'I': 20, 'L': 25, 'K': 47, 'M': 10, 'F': 17, 'P': 32, 'S': 43, 'T': 23, 'W': 7, 'Y': 5, 'V': 42

Frequencies of Amino Acids

'A': 11.03%, 'R': 5.43%, 'N': 6.3%, 'D': 8.41%, 'C': 0%, 'Q': 4.2%, 'E': 4.38%, 'G': 10.86%, 'H': 1.93%, 'I': 3.5%, 'L': 4.38%, 'K': 8.23%, 'M': 1.75%, 'F': 2.98%, 'P': 5.6%, 'S': 7.53%, 'T': 4.03%, 'W': 1.23%, 'Y': 0.88%, 'V': 7.36%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

278

Hydrophilic Amino Acid(s) Count

293

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	60709.3 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	63.1	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	38.076	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.738	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.729	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.608	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	6.046	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.203, 0.303, 0.215 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.051	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	45950, 45950	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Endonuclease, Hydrolase, Nuclease

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

No PMID found

5.2 Protein Sequence Databases

UniProt: A0A0G3F3H0

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A0G3F3H0

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	KP979588	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_052979305.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR024575, IPR037146, IPR024566, IPR044925, IPR003615, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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