AMPDB_3755 | Colicin-E1*

PEPTIDE SUMMARY

Colicin-E1*

1 General Description

AMPDB ID: AMPDB_3755

Protein Names: Colicin-E1*

Protein Family: Channel forming colicin family

Gene Name: cea

Source Organism: Shigella sonnei

Protein Length: 521 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

METAVAYYKDGVPYDDKGEVIITLLNGNPDGSGSGGGGGTGGSKSESSAAIHATAKWSTAQLKKTQAEQAARAKAAAEAQAKAKANRDALTQHLKDIVNEALRHNSTHPEVIDLLMPIMQRCRQKQSGCALQKQKKKPVKKRKRAEKSFQEAEQRRKEIEKEQAETERQLKLAEDEEKRLAALSEEARAVEVAQKNLAAAQSELAKVDEEINTLNTRLSSSIHARDAETNTLSGKRNELDQASAKYKELDERVKLLSPRANDPLQSRPFFEATRLRARRGDEMEEKQKQVTATETRLNQISSEINGIQEAISQANNKRSTAVSRIHDAEDNLKTAQTNLLNSQIKDAVDATVSFYQTLSEKYGEKYSKMAQELADKSKGKKISNVNEALAAFEKYKDVLNKKFSKADRDAIFNALEAVKYEDWAKHLDQFAKYLKITGHVSFGYDVVSDILKIKDTGDWKPLFLTLEKKAVDAGVSYVVVLLFSVLAGTTLGIWGIAIVTGILCAFIDKNKLNTINEVLGI

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 65, 'R': 26, 'N': 25, 'D': 30, 'C': 3, 'Q': 28, 'E': 45, 'G': 27, 'H': 8, 'I': 27, 'L': 46, 'K': 57, 'M': 5, 'F': 12, 'P': 9, 'S': 35, 'T': 29, 'W': 4, 'Y': 12, 'V': 28

Frequencies of Amino Acids

'A': 12.48%, 'R': 4.99%, 'N': 4.8%, 'D': 5.76%, 'C': 0.58%, 'Q': 5.37%, 'E': 8.64%, 'G': 5.18%, 'H': 1.54%, 'I': 5.18%, 'L': 8.83%, 'K': 10.94%, 'M': 0.96%, 'F': 2.3%, 'P': 1.73%, 'S': 6.72%, 'T': 5.57%, 'W': 0.77%, 'Y': 2.3%, 'V': 5.37%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

223

Hydrophilic Amino Acid(s) Count

298

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	57670.2 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	82.706	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	35.362	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.622	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.729	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.429	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	8.606	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.248, 0.184, 0.309 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.054	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	39880, 40005	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cell membrane, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

No PMID found

5.2 Protein Sequence Databases

UniProt: P21178

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P21178

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	M37218	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR000293, IPR038283

PANTHER: Not found

PROSITE: PS00276

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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