AMPDB_3741 | Sarcotoxin-2A

PEPTIDE SUMMARY

Sarcotoxin-2A

1 General Description

AMPDB ID: AMPDB_3741

Protein Names: Sarcotoxin-2A (Sarcotoxin IIA)

Protein Family: Attacin sarcotoxin-2 family

Gene Name: Nil

Source Organism: Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)

Protein Length: 294 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MKSFVFFAACMAIIALSSLVQAYPQKLPVPIPPPTNPPVAAFHNSVATNSKGGQDVSVKLAATNLGNKHVQPIAEVFAEGNTKGGNVLRGATVGVQGHGLGASVTKSQDGIAESFRKQAEANLRLGDSASLIGKVSQTDTKIKGIDFKPQLSSSSLALQGDRLGASISRDVNRGVSDTLTKSVSANLFRNDNHNLDASVFRSDVRQNNGFNFQKTGGMLDYSHANGHGLNAGLTRFSGIGNQATVGGYSTLFRSNDGLTSLKANAGGSQWLSGPFANQRDYSFGLGLSHNAWRG

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 29, 'R': 13, 'N': 23, 'D': 14, 'C': 1, 'Q': 15, 'E': 4, 'G': 35, 'H': 7, 'I': 10, 'L': 26, 'K': 15, 'M': 3, 'F': 15, 'P': 11, 'S': 32, 'T': 15, 'W': 2, 'Y': 4, 'V': 20

Frequencies of Amino Acids

'A': 9.86%, 'R': 4.42%, 'N': 7.82%, 'D': 4.76%, 'C': 0.34%, 'Q': 5.1%, 'E': 1.36%, 'G': 11.9%, 'H': 2.38%, 'I': 3.4%, 'L': 8.84%, 'K': 5.1%, 'M': 1.02%, 'F': 5.1%, 'P': 3.74%, 'S': 10.88%, 'T': 5.1%, 'W': 0.68%, 'Y': 1.36%, 'V': 6.8%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

151

Hydrophilic Amino Acid(s) Count

143

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	30820.5 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	77.347	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	26.248	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.272	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.795	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.503	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	10.578	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.262, 0.344, 0.211 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.071	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	16960, 16960	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Ando K, Natori S, Natori S. Molecular cloning, sequencing, and characterization of cDNA for sarcotoxin IIA, an inducible antibacterial protein of Sarcophaga peregrina (flesh fly). Biochemistry. 1988;27(5):1715-21. Published 1988 Mar 8. doi:10.1021/bi00405a050

PMID: 2452654

5.2 Protein Sequence Databases

UniProt: P14667

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P14667

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	M18873	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR005521, IPR005520

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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