AMPDB_3730 | Lycosin-II

PEPTIDE SUMMARY

Lycosin-II

1 General Description

AMPDB ID: AMPDB_3730

Protein Names: Lycosin-II

Protein Family: Cationic peptide 04 (cupiennin) family; 05 subfamily

Gene Name: Nil

Source Organism: Lycosa singoriensis (Wolf spider) (Aranea singoriensis)

Protein Length: 23 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

VWLSALKFIGKHLAKHQLSKLGR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 1, 'N': 0, 'D': 0, 'C': 0, 'Q': 1, 'E': 0, 'G': 2, 'H': 2, 'I': 1, 'L': 5, 'K': 4, 'M': 0, 'F': 1, 'P': 0, 'S': 2, 'T': 0, 'W': 1, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 8.7%, 'R': 4.35%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 4.35%, 'E': 0%, 'G': 8.7%, 'H': 8.7%, 'I': 4.35%, 'L': 21.74%, 'K': 17.39%, 'M': 0%, 'F': 4.35%, 'P': 0%, 'S': 8.7%, 'T': 0%, 'W': 4.35%, 'Y': 0%, 'V': 4.35%

Missing Amino Acid(s)

C, D, E, M, N, P, T, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

F, I, Q, R, V, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2631.21 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	123.043	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	3.857	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.035	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.576	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.997	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	5.179	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.391, 0.174, 0.304 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.087	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

A.baumannii (Gram-negative), E.coli (Gram-negative), P.aeruginosa (Gram-negative), S.aureus (Gram-positive), S.epidermidis (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-biofilm, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Anti-inflammatory, Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Wang Y, Wang L, Yang H, et al. The Spider Venom Peptide Lycosin-II Has Potent Antimicrobial Activity against Clinically Isolated Bacteria. Toxins (Basel). 2016;8(5). Published 2016 Apr 26. doi:10.3390/toxins8050119

PMID: 27128941

Citation 2: Oh JH, Park J, Park Y, et al. Anti-biofilm and anti-inflammatory effects of Lycosin-II isolated from spiders against multi-drug resistant bacteria. Biochim Biophys Acta Biomembr. 2022;1864(1):183769. Published 2022 Feb 1. doi:10.1016/j.bbamem.2021.183769

PMID: 34506798

5.2 Protein Sequence Databases

UniProt: P0DV71

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DV71

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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