AMPDB_3728 | Lycotoxin-Pa4a

PEPTIDE SUMMARY

Lycotoxin-Pa4a

1 General Description

AMPDB ID: AMPDB_3728

Protein Names: Lycotoxin-Pa4a (LCTX-Pa4a)

Protein Family: Neurotoxin 19 (CSTX) family

Gene Name: Nil

Source Organism: Pardosa astrigera (Wolf spider)

Protein Length: 122 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

2.1 Sequence

MKLGIFFSVFFLAMIHSCLSETNEDKNLESYFREDDLKALSFGEYARAMMAESRKDNCIPKHHECTSRPKDCCKQNLMQFKCSCMTIIDKNNKETERCKCDNSIFQKVAKTSVNIGKAVVTK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 7, 'R': 5, 'N': 8, 'D': 7, 'C': 9, 'Q': 3, 'E': 9, 'G': 3, 'H': 3, 'I': 7, 'L': 7, 'K': 15, 'M': 6, 'F': 8, 'P': 2, 'S': 10, 'T': 6, 'W': 0, 'Y': 2, 'V': 5

Frequencies of Amino Acids

'A': 5.74%, 'R': 4.1%, 'N': 6.56%, 'D': 5.74%, 'C': 7.38%, 'Q': 2.46%, 'E': 7.38%, 'G': 2.46%, 'H': 2.46%, 'I': 5.74%, 'L': 5.74%, 'K': 12.3%, 'M': 4.92%, 'F': 6.56%, 'P': 1.64%, 'S': 8.2%, 'T': 4.92%, 'W': 0%, 'Y': 1.64%, 'V': 4.1%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

P, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	14037.3 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	62.377	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	42.192	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.461	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.573	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.327	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.726	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.238, 0.189, 0.238 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.082	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	2980, 3480	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Anti-inflammatory, Signal peptide, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Shin MK, Hwang IW, Kim Y, et al. Antibacterial and Anti-Inflammatory Effects of Novel Peptide Toxin from the Spider Pardosa astrigera. Antibiotics (Basel). 2020;9(7). Published 2020 Jul 19. doi:10.3390/antibiotics9070422

PMID: 32707636

5.2 Protein Sequence Databases

UniProt: P0DV62

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DV62

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR019553, IPR011142

PANTHER: Not found

PROSITE: PS60029

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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