AMPDB_3724 | Conotoxin Cl14.1a

1 General Description

AMPDB ID: AMPDB_3724

Protein Names: Conotoxin Cl14.1a (Conotoxin Cal14.1a)

Protein Family: Conotoxin L superfamily

Gene Name: Nil

Source Organism: Californiconus californicus (California cone) (Conus californicus)

Protein Length: 66 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

MNVTAMFIVLLLTMPLTDGFNIRAINGGELFGLVQRDAGNALDHGFYRRGDCPPWCVGARCRAEKC

FASTA format

Counts of Amino Acids

'A': 6, 'R': 6, 'N': 4, 'D': 4, 'C': 4, 'Q': 1, 'E': 2, 'G': 8, 'H': 1, 'I': 3, 'L': 7, 'K': 1, 'M': 3, 'F': 4, 'P': 3, 'S': 0, 'T': 3, 'W': 1, 'Y': 1, 'V': 4

Frequencies of Amino Acids

'A': 9.09%, 'R': 9.09%, 'N': 6.06%, 'D': 6.06%, 'C': 6.06%, 'Q': 1.52%, 'E': 3.03%, 'G': 12.12%, 'H': 1.52%, 'I': 4.55%, 'L': 10.61%, 'K': 1.52%, 'M': 4.55%, 'F': 6.06%, 'P': 4.55%, 'S': 0%, 'T': 4.55%, 'W': 1.52%, 'Y': 1.52%, 'V': 6.06%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

H, K, Q, W, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7273.49 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	85.758	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	27.638	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.147	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.608	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	7.932	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.845	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.303, 0.227, 0.273 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.091	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	6990, 7240	Computed by ProtParam module (biopython 1.79)

4.1 Target Organism(s)

T.gondii, Toxoplasma gondii

4.2 Antimicrobial Activity

Antimicrobial, Anti-parasitic

4.3 Enzymatic Activity

4.4 Inhibitory Effect

4.5 Other Biological Activity

Toxin, Anti-cancer, Synergistic peptide, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

Citation 1: Biggs JS, Watkins M, Puillandre N, et al. Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol Phylogenet Evol. 2010;56(1):1-12. Published 2010 Jul. doi:10.1016/j.ympev.2010.03.029

PMID: 20363338

Citation 2: De LeÃ³n-Nava MA, Romero-NÃºÃ±ez E, Luna-Nophal A, et al. In Vitro Effect of the Synthetic cal14.1a Conotoxin, Derived from Conus californicus, on the Human Parasite Toxoplasma gondii. Mar Drugs. 2016;14(4). Published 2016 Apr 8. doi:10.3390/md14040066

PMID: 27070627

Citation 3: Oroz-Parra I, Navarro M, Cervantes-Luevano KE, et al. Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom. Toxins (Basel). 2016;8(2):38. Published 2016 Feb 5. doi:10.3390/toxins8020038

PMID: 26861394

Citation 4: Jiang H, Li L, Zhang J, et al. MiR-101-3p and Syn-Cal14.1a Synergy in Suppressing EZH2-Induced Progression of Breast Cancer. Onco Targets Ther. 2020;13:9599-9609. Published 2020. doi:10.2147/OTT.S264600

PMID: 33061442

5.2 Protein Sequence Databases

5.3 3D Structure Databases

AlphaFoldDB: P0DUQ5

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	FJ959129	GenBank \|\| EMBL

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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