AMPDB_3710 | Dermaseptin-N1

PEPTIDE SUMMARY

Dermaseptin-N1

1 General Description

AMPDB ID: AMPDB_3710

Protein Names: Dermaseptin-N1 (DRS-N1) (Dermaseptin-H10) (DRS-H10)

Protein Family: Frog skin active peptide (FSAP) family; Dermaseptin subfamily

Gene Name: Nil

Source Organism: Pithecopus nordestinus (Northeastern Brazilian leaf frog) (Phyllomedusa nordestina)

Protein Length: 20 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GLWSTIKNVAAAAGKAAIKL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 6, 'R': 0, 'N': 1, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 2, 'H': 0, 'I': 2, 'L': 2, 'K': 3, 'M': 0, 'F': 0, 'P': 0, 'S': 1, 'T': 1, 'W': 1, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 30%, 'R': 0%, 'N': 5%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 10%, 'H': 0%, 'I': 10%, 'L': 10%, 'K': 15%, 'M': 0%, 'F': 0%, 'P': 0%, 'S': 5%, 'T': 5%, 'W': 5%, 'Y': 0%, 'V': 5%

Missing Amino Acid(s)

C, D, E, F, H, M, P, Q, R, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

N, S, T, V, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1983.38 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	122.5	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	4.36	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.66	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.488	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.103	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.997	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.3, 0.2, 0.4 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.05	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), L.amazonensis, L.infantum, Leishmania, Leishmania species, S.aureus (Gram-positive), Xanthomonas axonopodis (Gram-negative)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytotoxin, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Brand GD, Santos RC, Arake LM, et al. The skin secretion of the amphibian Phyllomedusa nordestina: a source of antimicrobial and antiprotozoal peptides. Molecules. 2013;18(6):7058-70. Published 2013 Jun 17. doi:10.3390/molecules18067058

PMID: 23774944

5.2 Protein Sequence Databases

UniProt: P0DTD4

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DTD4

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR022731

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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