AMPDB_3709 | Toxin Cm38

PEPTIDE SUMMARY

Toxin Cm38

1 General Description

AMPDB ID: AMPDB_3709

Protein Names: Toxin Cm38

Protein Family: Long (4 C-C) scorpion toxin superfamily; Sodium channel inhibitor family

Gene Name: Nil

Source Organism: Centruroides margaritatus (Central American bark Scorpion)

Protein Length: 19 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

ARDGYIVDEKGCKFACFIN

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 1, 'N': 1, 'D': 2, 'C': 2, 'Q': 0, 'E': 1, 'G': 2, 'H': 0, 'I': 2, 'L': 0, 'K': 2, 'M': 0, 'F': 2, 'P': 0, 'S': 0, 'T': 0, 'W': 0, 'Y': 1, 'V': 1

Frequencies of Amino Acids

'A': 10.53%, 'R': 5.26%, 'N': 5.26%, 'D': 10.53%, 'C': 10.53%, 'Q': 0%, 'E': 5.26%, 'G': 10.53%, 'H': 0%, 'I': 10.53%, 'L': 0%, 'K': 10.53%, 'M': 0%, 'F': 10.53%, 'P': 0%, 'S': 0%, 'T': 0%, 'W': 0%, 'Y': 5.26%, 'V': 5.26%

Missing Amino Acid(s)

H, L, M, P, Q, S, T, W

Most Occurring Amino Acid(s)

A, C, D, F, G, I, K

Less Occurring Amino Acid(s)

E, N, R, V, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2149.47 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	66.842	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	11.284	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.053	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.388	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.28	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-0.125	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.316, 0.158, 0.158 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.158	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	1490, 1615	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

K.pneumoniae (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Toxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: DueÃ±as-Cuellar RA, Kushmerick C, Naves LA, et al. Cm38: a new antimicrobial peptide active against Klebsiella pneumoniae is homologous to Cn11. Protein Pept Lett. 2015;22(2):164-72. Published 2015. doi:10.2174/092986652202150128143048

PMID: 25633390

5.2 Protein Sequence Databases

UniProt: P0DTB8

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DTB8

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR044062, IPR002061

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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