AMPDB_3693 | Buforin-2
PEPTIDE SUMMARY
Buforin-2
1 General Description
AMPDB ID: AMPDB_3693
Protein Names: Buforin-2 (BF2) (Buforin II)
Protein Family: Histone H2A family
Gene Name: Nil
Protein Length: 21 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
TRSSRAGLQFPVGRVHRLLRK
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 1, 'R': 5, 'N': 0, 'D': 0, 'C': 0, 'Q': 1, 'E': 0, 'G': 2, 'H': 1, 'I': 0, 'L': 3, 'K': 1, 'M': 0, 'F': 1, 'P': 1, 'S': 2, 'T': 1, 'W': 0, 'Y': 0, 'V': 2
Frequencies of Amino Acids
'A': 4.76%, 'R': 23.81%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 4.76%, 'E': 0%, 'G': 9.52%, 'H': 4.76%, 'I': 0%, 'L': 14.29%, 'K': 4.76%, 'M': 0%, 'F': 4.76%, 'P': 4.76%, 'S': 9.52%, 'T': 4.76%, 'W': 0%, 'Y': 0%, 'V': 9.52%
Missing Amino Acid(s)
C, D, E, I, M, N, W, Y
Most Occurring Amino Acid(s)
R
Less Occurring Amino Acid(s)
A, F, H, K, P, Q, T
Hydrophobic Amino Acid(s) Count
10
Hydrophilic Amino Acid(s) Count
11
Basic Amino Acid(s) Count
0
Acidic Amino Acid(s) Count
7
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 2434.88 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 88.095 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 84.195 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.638 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.806 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 13.105 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 6.089 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.286, 0.238, 0.19 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.048 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 0, 0 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
E.coli (Gram-negative)
4.2 Antimicrobial Activity
Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide, Anti-gram-negative
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Cytotoxin, Hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Muñoz-Camargo C, Salazar VA, Barrero-Guevara L, et al. Unveiling the Multifaceted Mechanisms of Antibacterial Activity of Buforin II and Frenatin 2.3S Peptides from Skin Micro-Organs of the Orinoco Lime Treefrog (Sphaenorhynchus lacteus). Int J Mol Sci. 2018;19(8). Published 2018 Jul 25. doi:10.3390/ijms19082170
PMID: 30044391
5.2 Protein Sequence Databases
UniProt: P0DQL2
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P0DQL2
5.4 Nucleotide Sequence Databases
No entries found in GenBank or EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR009072, IPR032458
PANTHER: Not found
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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