AMPDB_3692 | Ocellatin-L1

PEPTIDE SUMMARY

Ocellatin-L1

1 General Description

AMPDB ID: AMPDB_3692

Protein Names: Ocellatin-L1

Protein Family: Frog skin active peptide (FSAP) family; Ocellatin subfamily

Gene Name: Nil

Source Organism: Leptodactylus laticeps (Santa Fe frog)

Protein Length: 25 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GVVDILKGAAKDLAGHLATKVMNKL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 4, 'R': 0, 'N': 1, 'D': 2, 'C': 0, 'Q': 0, 'E': 0, 'G': 3, 'H': 1, 'I': 1, 'L': 4, 'K': 4, 'M': 1, 'F': 0, 'P': 0, 'S': 0, 'T': 1, 'W': 0, 'Y': 0, 'V': 3

Frequencies of Amino Acids

'A': 16%, 'R': 0%, 'N': 4%, 'D': 8%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 12%, 'H': 4%, 'I': 4%, 'L': 16%, 'K': 16%, 'M': 4%, 'F': 0%, 'P': 0%, 'S': 0%, 'T': 4%, 'W': 0%, 'Y': 0%, 'V': 12%

Missing Amino Acid(s)

C, E, F, P, Q, R, S, W, Y

Most Occurring Amino Acid(s)

A, K, L

Less Occurring Amino Acid(s)

H, I, M, N, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2563.1 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	128.8	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	3.784	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.408	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.571	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.333	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.089	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.32, 0.16, 0.36 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Conlon JM, Al-Ghaferi N, Abraham B, et al. Purification and properties of laticeptin, an antimicrobial peptide from skin secretions of the South American frog Leptodactylus laticeps. Protein Pept Lett. 2006;13(4):411-5. Published 2006. doi:10.2174/092986606775974410

PMID: 16712520

Citation 2: Conlon JM, Abdel-Wahab YH, Flatt PR, et al. A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae). Peptides. 2009;30(5):888-92. Published 2009 May. doi:10.1016/j.peptides.2009.01.008

PMID: 19428765

5.2 Protein Sequence Databases

UniProt: P0DQL0

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DQL0

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR012518

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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