AMPDB_3691 | Medusin-L1

PEPTIDE SUMMARY

Medusin-L1

1 General Description

AMPDB ID: AMPDB_3691

Protein Names: Medusin-L1 (MDS-L1) (Phylloseptin-L1) (PLS-L1)

Protein Family: Frog skin active peptide (FSAP) family; Medusin subfamily

Gene Name: Nil

Source Organism: Agalychnis lemur (Lemur leaf frog) (Hylomantis lemur)

Protein Length: 18 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

LLGMIPLAISAISALSKL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 3, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 1, 'H': 0, 'I': 3, 'L': 5, 'K': 1, 'M': 1, 'F': 0, 'P': 1, 'S': 3, 'T': 0, 'W': 0, 'Y': 0, 'V': 0

Frequencies of Amino Acids

'A': 16.67%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 5.56%, 'H': 0%, 'I': 16.67%, 'L': 27.78%, 'K': 5.56%, 'M': 5.56%, 'F': 0%, 'P': 5.56%, 'S': 16.67%, 'T': 0%, 'W': 0%, 'Y': 0%, 'V': 0%

Missing Amino Acid(s)

C, D, E, F, H, N, Q, R, T, V, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

G, K, M, P

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1811.3 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	190	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	3.128	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	1.75	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.402	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.7	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.998	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.444, 0.278, 0.5 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.dendrobatidis, E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Anti-cancer, Cytolytic, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Conlon JM, Woodhams DC, Raza H, et al. Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae). Toxicon. 2007;50(4):498-506. Published 2007 Sep 15. doi:10.1016/j.toxicon.2007.04.017

PMID: 17561225

Citation 2: Amiche M, Ladram A, Nicolas P, et al. A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae. Peptides. 2008;29(11):2074-82. Published 2008 Nov. doi:10.1016/j.peptides.2008.06.017

PMID: 18644413

5.2 Protein Sequence Databases

UniProt: P0DQK9

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DQK9

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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