AMPDB_3690 | Brevinin-2-related peptide

PEPTIDE SUMMARY

Brevinin-2-related peptide

1 General Description

AMPDB ID: AMPDB_3690

Protein Names: Brevinin-2-related peptide

Protein Family: Frog skin active peptide (FSAP) family; Brevinin subfamily

Gene Name: Nil

Source Organism: Lithobates septentrionalis (Mink frog) (Rana septentrionalis)

Protein Length: 21 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GIWDTIKSMGKVFAGKILQNL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 1, 'D': 1, 'C': 0, 'Q': 1, 'E': 0, 'G': 3, 'H': 0, 'I': 3, 'L': 2, 'K': 3, 'M': 1, 'F': 1, 'P': 0, 'S': 1, 'T': 1, 'W': 1, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 4.76%, 'R': 0%, 'N': 4.76%, 'D': 4.76%, 'C': 0%, 'Q': 4.76%, 'E': 0%, 'G': 14.29%, 'H': 0%, 'I': 14.29%, 'L': 9.52%, 'K': 14.29%, 'M': 4.76%, 'F': 4.76%, 'P': 0%, 'S': 4.76%, 'T': 4.76%, 'W': 4.76%, 'Y': 0%, 'V': 4.76%

Missing Amino Acid(s)

C, E, H, P, R, Y

Most Occurring Amino Acid(s)

G, I, K

Less Occurring Amino Acid(s)

A, D, F, M, N, Q, S, T, V, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2319.79 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	111.429	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	2.805	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.286	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.613	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.507	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.998	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.381, 0.238, 0.19 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.095	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

C.albicans, E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Antiviral protein, Fungicide, Anti-HIV, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Bevier CR, Sonnevend A, Kolodziejek J, et al. Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis). Comp Biochem Physiol C Toxicol Pharmacol. 2004;139(1-3):31-8. Published 2004 Oct. doi:10.1016/j.cca.2004.08.019

PMID: 15556063

Citation 2: Wang G, Watson KM, Peterkofsky A, et al. Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. Antimicrob Agents Chemother. 2010;54(3):1343-6. Published 2010 Mar. doi:10.1128/AAC.01448-09

PMID: 20086159

5.2 Protein Sequence Databases

UniProt: P0DQK8

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DQK8

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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