AMPDB_36842 | HNH nuclease
PEPTIDE SUMMARY
HNH nuclease
1 General Description
AMPDB ID: AMPDB_36842
Protein Names: HNH nuclease (Hcp1 family type VI secretion system effector) (Type VI secretion system tube protein Hcp)
Protein Family: Colicin pyosin nuclease family
Gene Name: hcp BON84_03665 BON88_11445 EA435_09070 ELT16_19925 ELT24_04210 ELT25_17920 ELT32_04445 ELT35_06500 ELT36_14365 ELT39_06175 ELT44_07500 ELT48_11840 ELT54_16920 ELT60_04975 ELT61_09080 ELT63_20130 ELU96_07855 ELU98_12540 ELV01_06175 ELV02_11835 ELV03_12335 ELV12_03785 ELV13_01905 ELX68_14150 ELX79_16790 G3565_17825 GRC73_19030 GUI33_00485 HIE29_003035 HmCms169_00296
Source Organism: Escherichia coli
Protein Length: 593 AA
Protein Existence: Inferred from homology
2 Protein Sequence & Composition
2.1 Sequence
MGDIVYLRIIGEKQGDISSGCGTYASVGNRWQVGHEDEIFAFALTNAITSTGNGVNLQGLQFCKLIDKSSPLLSNAINQNERLFIEIDLYRINKSGRWERYYYIQLRNASLTAIHVNISDNNLPTECVTVDYDYILCKHLIANTEFDWLAFPAGYNSLFIPPKSPPASNLKPEPLPVVNLPLSSPAVNPVYAKSCLKVKGCTDAGTAEEPAENFGQVAIFVQPVVDDCCGYHHPEANVIGEPAEAQTMLLFPSSVLATQIWGKWSLSGVLSATRGSYIGALASALYIPSAGEGSARVPGRDEFWYEEELRQKALAGSTATTRVRFFWGTDIHGKPQVYGVHTGEGTPYENVRVANMQWNEQTQRYEFTPAHDVDGPLITWTPENPEHGNVPGHTGNDRPPLEQPTILVTPIPDGTDTYTTPPFPVPDPKEFNDYILVFPAGSGIKPIYVYLKEDPRKLPGVVTGHGVPLSPGTRWLDMSVSNNGNGAPIPAHIVDKLRGREFKTFDEFREALWLEVSQEPELIAQFSEINQLRISQGFTPFAPDEGHYIGPKETLKKFQIHHFIAIEYGGGVYDIDNLRIVTPRLHDEIHYRR
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 39, 'R': 26, 'N': 31, 'D': 29, 'C': 8, 'Q': 21, 'E': 40, 'G': 50, 'H': 17, 'I': 41, 'L': 46, 'K': 22, 'M': 4, 'F': 25, 'P': 50, 'S': 33, 'T': 36, 'W': 11, 'Y': 25, 'V': 39
Frequencies of Amino Acids
'A': 6.58%, 'R': 4.38%, 'N': 5.23%, 'D': 4.89%, 'C': 1.35%, 'Q': 3.54%, 'E': 6.75%, 'G': 8.43%, 'H': 2.87%, 'I': 6.91%, 'L': 7.76%, 'K': 3.71%, 'M': 0.67%, 'F': 4.22%, 'P': 8.43%, 'S': 5.56%, 'T': 6.07%, 'W': 1.85%, 'Y': 4.22%, 'V': 6.58%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
G, P
Less Occurring Amino Acid(s)
M
Hydrophobic Amino Acid(s) Count
305
Hydrophilic Amino Acid(s) Count
288
Basic Amino Acid(s) Count
69
Acidic Amino Acid(s) Count
65
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 65822.2 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 82.867 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 40.136 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.31 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.558 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 5.16 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) -19.896 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.315, 0.277, 0.218 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.103 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 97750, 98250 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
E.coli (Gram-negative)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative
4.3 Enzymatic Activity
Hydrolase
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Souvorov A, Agarwala R, Lipman DJ, et al. SKESA: strategic k-mer extension for scrupulous assemblies. Genome Biol. 2018;19(1):153. Published 2018 Oct 4. doi:10.1186/s13059-018-1540-z
PMID: 30286803
Citation 2: Poyet M, Groussin M, Gibbons SM, et al. A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research. Nat Med. 2019;25(9):1442-1452. Published 2019 Sep. doi:10.1038/s41591-019-0559-3
PMID: 31477907
5.2 Protein Sequence Databases
UniProt: A0A061YH55
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: A0A061YH55
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. BFLL01000003 GenBank || EMBL
2. DABBJX010000024 GenBank || EMBL
3. DABCJL010000006 GenBank || EMBL
4. RDVW01000006 GenBank || EMBL
5. WXOK01000001 GenBank || EMBL
6. JAAHTF010000015 GenBank || EMBL
7. MTXR01000015 GenBank || EMBL
8. MTXV01000051 GenBank || EMBL
9. RZEU01000044 GenBank || EMBL
10. RZEB01000023 GenBank || EMBL
11. RZDI01000003 GenBank || EMBL
12. RZDF01000036 GenBank || EMBL
13. RZCY01000008 GenBank || EMBL
14. RZCI01000003 GenBank || EMBL
15. RZCG01000010 GenBank || EMBL
16. RZCE01000005 GenBank || EMBL
17. RZCB01000008 GenBank || EMBL
18. RZBO01000005 GenBank || EMBL
19. RZBN01000003 GenBank || EMBL
20. RZBL01000005 GenBank || EMBL
21. RZBM01000132 GenBank || EMBL
22. RZAW01000005 GenBank || EMBL
23. RZAU01000026 GenBank || EMBL
24. RZAZ01000044 GenBank || EMBL
25. RZAS01000004 GenBank || EMBL
26. RZAK01000007 GenBank || EMBL
27. RZAP01000005 GenBank || EMBL
28. RZAM01000022 GenBank || EMBL
29. RZAG01000003 GenBank || EMBL
30. RZAD01000018 GenBank || EMBL
CCDS: Not found
RefSeq: WP_000502513.1
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR037146, IPR036624, IPR044925, IPR003615, IPR016128, IPR036302, IPR008514
PANTHER: Not found
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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