AMPDB_367 | Invertebrate-type lysozyme
PEPTIDE SUMMARY
Invertebrate-type lysozyme
1 General Description
AMPDB ID: AMPDB_367
Protein Names: Invertebrate-type lysozyme (EC 3.2.1.17) (1;4-beta-N-acetylmuramidase) (Destabilase)
Protein Family: Glycosyl hydrolase 22 family; Type-I lysozyme subfamily
Gene Name: Nil
Protein Length: 136 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
METVSVEEGLDFAPGMVSQKCLLCMCKLESGGCKPIGCRMDVGSLSCGYFQIKQPYWIDCGKPGKDWKSCSNDINCSSKCVQQYMKRYATHYRCPLNCEGFAREHNGGPNGCHSSRTLKYWELLQKIPGCKGVKFS
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 3, 'R': 5, 'N': 5, 'D': 5, 'C': 14, 'Q': 6, 'E': 7, 'G': 15, 'H': 3, 'I': 5, 'L': 9, 'K': 13, 'M': 5, 'F': 4, 'P': 7, 'S': 12, 'T': 3, 'W': 3, 'Y': 6, 'V': 6
Frequencies of Amino Acids
'A': 2.21%, 'R': 3.68%, 'N': 3.68%, 'D': 3.68%, 'C': 10.29%, 'Q': 4.41%, 'E': 5.15%, 'G': 11.03%, 'H': 2.21%, 'I': 3.68%, 'L': 6.62%, 'K': 9.56%, 'M': 3.68%, 'F': 2.94%, 'P': 5.15%, 'S': 8.82%, 'T': 2.21%, 'W': 2.21%, 'Y': 4.41%, 'V': 4.41%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
G
Less Occurring Amino Acid(s)
A, H, T, W
Hydrophobic Amino Acid(s) Count
57
Hydrophilic Amino Acid(s) Count
79
Basic Amino Acid(s) Count
12
Acidic Amino Acid(s) Count
21
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 15197.6 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 55.147 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 39.043 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.439 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.618 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 8.319 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 5.409 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.243, 0.287, 0.176 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.096 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 25440, 26315 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
M.luteus (Gram-negative)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Bacteriolytic enzyme, Anti-gram-negative
4.3 Enzymatic Activity
Glycosidase, Hydrolase
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Takeshita K, Hashimoto Y, Thujihata Y, et al. Determination of the complete cDNA sequence, construction of expression systems, and elucidation of fibrinolytic activity for Tapes japonica lysozyme. Protein Expr Purif. 2004;36(2):254-62. Published 2004 Aug. doi:10.1016/j.pep.2004.05.001
PMID: 15249048
Citation 2: Ito Y, Yoshikawa A, Hotani T, et al. Amino acid sequences of lysozymes newly purified from invertebrates imply wide distribution of a novel class in the lysozyme family. Eur J Biochem. 1999;259(1-2):456-61. Published 1999 Jan. doi:10.1046/j.1432-1327.1999.00064.x
PMID: 9914527
Citation 3: Takeshita K, Hashimoto Y, Ueda T, et al. A small chimerically bifunctional monomeric protein: Tapes japonica lysozyme. Cell Mol Life Sci. 2003;60(9):1944-51. Published 2003 Sep. doi:10.1007/s00018-003-3082-z
PMID: 14523554
Citation 4: Goto T, Abe Y, Kakuta Y, et al. Crystal structure of Tapes japonica Lysozyme with substrate analogue: structural basis of the catalytic mechanism and manifestation of its chitinase activity accompanied by quaternary structural change. J Biol Chem. 2007;282(37):27459-27467. Published 2007 Sep 14. doi:10.1074/jbc.M704555200
PMID: 17631496
5.2 Protein Sequence Databases
UniProt: Q8IU26
5.3 3D Structure Databases
Sl. no. PDB ID Method Resolution Access Links 3D View
AlphaFoldDB: Q8IU26
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. AB091383 GenBank || EMBL
2. AB055701 GenBank || EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR008597, IPR023346
PANTHER: PTHR11195
PROSITE: PS51909
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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