AMPDB_3602 | Caerin-3.5

PEPTIDE SUMMARY

Caerin-3.5

1 General Description

AMPDB ID: AMPDB_3602

Protein Names: Caerin-3.5

Protein Family: Frog skin active peptide (FSAP) family; Caerin subfamily

Gene Name: Nil

Source Organism: Ranoidea gracilenta (Dainty green tree frog) (Litoria gracilenta)

Protein Length: 22 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GLWEKVKEKANELVSGIVEGVK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 1, 'D': 0, 'C': 0, 'Q': 0, 'E': 4, 'G': 3, 'H': 0, 'I': 1, 'L': 2, 'K': 4, 'M': 0, 'F': 0, 'P': 0, 'S': 1, 'T': 0, 'W': 1, 'Y': 0, 'V': 4

Frequencies of Amino Acids

'A': 4.55%, 'R': 0%, 'N': 4.55%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 18.18%, 'G': 13.64%, 'H': 0%, 'I': 4.55%, 'L': 9.09%, 'K': 18.18%, 'M': 0%, 'F': 0%, 'P': 0%, 'S': 4.55%, 'T': 0%, 'W': 4.55%, 'Y': 0%, 'V': 18.18%

Missing Amino Acid(s)

C, D, F, H, M, P, Q, R, T, Y

Most Occurring Amino Acid(s)

E, K, V

Less Occurring Amino Acid(s)

A, I, N, S, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2412.81 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	110.455	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	6.114	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.241	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.56	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.664	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.004	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.364, 0.227, 0.318 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.045	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Maclean MJ, Brinkworth CS, Bilusich D, et al. New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry. Toxicon. 2006;47(6):664-75. Published 2006 May. doi:10.1016/j.toxicon.2006.01.019

PMID: 16554081

5.2 Protein Sequence Databases

UniProt: P0C2A9

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0C2A9

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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