AMPDB_3587 | Piscidin-3

PEPTIDE SUMMARY

Piscidin-3

1 General Description

AMPDB ID: AMPDB_3587

Protein Names: Piscidin-3

Protein Family: Pleurocidin family

Gene Name: Nil

Source Organism: Morone chrysops x Morone saxatilis (White bass x Striped bass)

Protein Length: 22 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

FIHHIFRGIVHAGRSIGRFLTG

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 3, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 4, 'H': 3, 'I': 4, 'L': 1, 'K': 0, 'M': 0, 'F': 3, 'P': 0, 'S': 1, 'T': 1, 'W': 0, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 4.55%, 'R': 13.64%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 18.18%, 'H': 13.64%, 'I': 18.18%, 'L': 4.55%, 'K': 0%, 'M': 0%, 'F': 13.64%, 'P': 0%, 'S': 4.55%, 'T': 4.55%, 'W': 0%, 'Y': 0%, 'V': 4.55%

Missing Amino Acid(s)

C, D, E, K, M, N, P, Q, W, Y

Most Occurring Amino Acid(s)

G, I

Less Occurring Amino Acid(s)

A, L, S, T, V

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2491.93 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	106.364	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	39.664	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.455	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.781	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	12.801	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.271	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.409, 0.227, 0.091 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.136	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Antiviral protein, Anti-HSV, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Silphaduang U, Noga EJ, Noga EJ. Peptide antibiotics in mast cells of fish. Nature. 2001;414(6861):268-9. Published 2001 Nov 15. doi:10.1038/35104690

PMID: 11713517

Citation 2: Chinchar VG, Bryan L, Silphadaung U, et al. Inactivation of viruses infecting ectothermic animals by amphibian and piscine antimicrobial peptides. Virology. 2004;323(2):268-75. Published 2004 Jun 1. doi:10.1016/j.virol.2004.02.029

PMID: 15193922

Citation 3: Perrin BS Jr, Tian Y, Fu R, et al. High-resolution structures and orientations of antimicrobial peptides piscidin 1 and piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion. J Am Chem Soc. 2014;136(9):3491-504. Published 2014 Mar 5. doi:10.1021/ja411119m

PMID: 24410116

5.2 Protein Sequence Databases

UniProt: P0C006

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P0C006

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR012515

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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