AMPDB_3542 | Moricin-2

PEPTIDE SUMMARY

Moricin-2

1 General Description

AMPDB ID: AMPDB_3542

Protein Names: Moricin-2

Protein Family: Moricin family

Gene Name: MOR2

Source Organism: Bombyx mori (Silk moth)

Protein Length: 66 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MNILKLFFVFIVAMSLVSCSTAAPAKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 9, 'R': 2, 'N': 4, 'D': 1, 'C': 1, 'Q': 0, 'E': 0, 'G': 3, 'H': 1, 'I': 7, 'L': 5, 'K': 10, 'M': 2, 'F': 5, 'P': 3, 'S': 4, 'T': 3, 'W': 0, 'Y': 0, 'V': 6

Frequencies of Amino Acids

'A': 13.64%, 'R': 3.03%, 'N': 6.06%, 'D': 1.52%, 'C': 1.52%, 'Q': 0%, 'E': 0%, 'G': 4.55%, 'H': 1.52%, 'I': 10.61%, 'L': 7.58%, 'K': 15.15%, 'M': 3.03%, 'F': 7.58%, 'P': 4.55%, 'S': 6.06%, 'T': 4.55%, 'W': 0%, 'Y': 0%, 'V': 9.09%

Missing Amino Acid(s)

E, Q, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, D, H

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7128.73 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	110.909	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	32.08	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.488	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.748	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.647	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	11.024	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.348, 0.212, 0.242 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.076	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Furukawa S, Tanaka H, Nakazawa H, et al. Inducible gene expression of moricin, a unique antibacterial peptide from the silkworm (Bombyx mori). Biochem J. 1999;340 ( Pt 1)(Pt 1):265-71. Published 1999 May 15. doi:

PMID: 10229682

Citation 2: Hara S, Yamakawa M, Yamakawa M. Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori. J Biol Chem. 1995;270(50):29923-7. Published 1995 Dec 15. doi:10.1074/jbc.270.50.29923

PMID: 8530391

5.2 Protein Sequence Databases

UniProt: O96059

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: O96059

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AB014092	GenBank \|\| EMBL
2.	AB019538	GenBank \|\| EMBL

CCDS: Not found

RefSeq: NP_001036829.2

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR009456, IPR037043

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: bmor:692365

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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