AMPDB_3518 | Neuropeptide-like protein 29

1 General Description

AMPDB ID: AMPDB_3518

Protein Names: Neuropeptide-like protein 29 [Cleaved into: QWGYGGY-amide; GYGGYGGY-amide; GMYGGY-amide; GMYGGW-amide]

Protein Family: YARP (YGGW-amide related peptide) family

Gene Name: nlp-29 B0213.4

Source Organism: Caenorhabditis elegans

Protein Length: 73 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

MISTSSILVLVVLLACFMAASAQWGYGGYGRGYGGYGGYGRGMYGGYGRGMYGGYGRGMYGGYGRGMYGGWGK

FASTA format

Counts of Amino Acids

'A': 4, 'R': 5, 'N': 0, 'D': 0, 'C': 1, 'Q': 1, 'E': 0, 'G': 26, 'H': 0, 'I': 2, 'L': 4, 'K': 1, 'M': 6, 'F': 1, 'P': 0, 'S': 4, 'T': 1, 'W': 2, 'Y': 12, 'V': 3

Frequencies of Amino Acids

'A': 5.48%, 'R': 6.85%, 'N': 0%, 'D': 0%, 'C': 1.37%, 'Q': 1.37%, 'E': 0%, 'G': 35.62%, 'H': 0%, 'I': 2.74%, 'L': 5.48%, 'K': 1.37%, 'M': 8.22%, 'F': 1.37%, 'P': 0%, 'S': 5.48%, 'T': 1.37%, 'W': 2.74%, 'Y': 16.44%, 'V': 4.11%

Missing Amino Acid(s)

D, E, H, N, P

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, F, K, Q, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7616.7 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	49.452	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	16.269	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.012	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.422	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.8	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	5.925	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.329, 0.411, 0.192 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.205	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	28880, 28880	Computed by ProtParam module (biopython 1.79)

4.1 Target Organism(s)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide

4.3 Enzymatic Activity

4.4 Inhibitory Effect

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

Citation 1: C. elegans Sequencing Consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science. 1998;282(5396):2012-8. Published 1998 Dec 11. doi:10.1126/science.282.5396.2012

PMID: 9851916

Citation 2: Nathoo AN, Moeller RA, Westlund BA, et al. Identification of neuropeptide-like protein gene families in Caenorhabditiselegans and other species. Proc Natl Acad Sci U S A. 2001;98(24):14000-5. Published 2001 Nov 20. doi:10.1073/pnas.241231298

PMID: 11717458

Citation 3: Couillault C, Pujol N, Reboul J, et al. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Nat Immunol. 2004;5(5):488-94. Published 2004 May. doi:10.1038/ni1060

PMID: 15048112

Citation 4: Pujol N, Cypowyj S, Ziegler K, et al. Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr Biol. 2008;18(7):481-9. Published 2008 Apr 8. doi:10.1016/j.cub.2008.02.079

PMID: 18394898

Citation 5: Ziegler K, Kurz CL, Cypowyj S, et al. Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Cell Host Microbe. 2009;5(4):341-52. Published 2009 Apr 23. doi:10.1016/j.chom.2009.03.006

PMID: 19380113

5.2 Protein Sequence Databases

5.3 3D Structure Databases

AlphaFoldDB: O44664

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	FO080121	GenBank \|\| EMBL

RefSeq: NP_504109.1

5.5 Protein-Protein Interaction Databases

STRING: 6239.B0213.4

IntAct: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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