AMPDB_35162 | Bacteriocin E50-52

PEPTIDE SUMMARY

Bacteriocin E50-52

1 General Description

AMPDB ID: AMPDB_35162

Protein Names: Bacteriocin E50-52

Protein Family: Bacteriocin class IIA YGNGV family

Gene Name: Nil

Source Organism: Enterococcus faecium (Streptococcus faecium)

Protein Length: 39 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

TTKNYGNGVCNSVNWCQCGNVWASCNLATGCAAWLCKLA

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 5, 'R': 0, 'N': 6, 'D': 0, 'C': 6, 'Q': 1, 'E': 0, 'G': 4, 'H': 0, 'I': 0, 'L': 3, 'K': 2, 'M': 0, 'F': 0, 'P': 0, 'S': 2, 'T': 3, 'W': 3, 'Y': 1, 'V': 3

Frequencies of Amino Acids

'A': 12.82%, 'R': 0%, 'N': 15.38%, 'D': 0%, 'C': 15.38%, 'Q': 2.56%, 'E': 0%, 'G': 10.26%, 'H': 0%, 'I': 0%, 'L': 7.69%, 'K': 5.13%, 'M': 0%, 'F': 0%, 'P': 0%, 'S': 5.13%, 'T': 7.69%, 'W': 7.69%, 'Y': 2.56%, 'V': 7.69%

Missing Amino Acid(s)

D, E, F, H, I, M, P, R

Most Occurring Amino Acid(s)

C, N

Less Occurring Amino Acid(s)

Q, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	4125.71 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	65.128	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	-3.851	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.164	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.449	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.111	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.625	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.256, 0.308, 0.205 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.103	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	17990, 18365	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

C.jejuni (Gram-negative), L.monocytogenes (Gram-positive), Listeria spp. (Gram-positive), S.aureus (Gram-positive), S.enteritidis, S.epidermidis (Gram-positive), Y.enterocolitica (Gram-negative), Y.pseudotuberculosis (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-listeria, Anti-tuberculosis, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Svetoch EA, Eruslanov BV, Perelygin VV, et al. Diverse antimicrobial killing by Enterococcus faecium E 50-52 bacteriocin. J Agric Food Chem. 2008;56(6):1942-8. Published 2008 Mar 26. doi:10.1021/jf073284g

PMID: 18293921

5.2 Protein Sequence Databases

UniProt: P85148

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P85148

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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