AMPDB_35125 | Ribosome-inactivating protein luffacylin

PEPTIDE SUMMARY

Ribosome-inactivating protein luffacylin

1 General Description

AMPDB ID: AMPDB_35125

Protein Names: Ribosome-inactivating protein luffacylin (EC 3.2.2.22) (rRNA N-glycosidase)

Protein Family: Nil

Gene Name: Nil

Source Organism: Luffa aegyptiaca (Sponge gourd) (Luffa cylindrica)

Protein Length: 14 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

PRGSPRTEYEAARR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 4, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 2, 'G': 1, 'H': 0, 'I': 0, 'L': 0, 'K': 0, 'M': 0, 'F': 0, 'P': 2, 'S': 1, 'T': 1, 'W': 0, 'Y': 1, 'V': 0

Frequencies of Amino Acids

'A': 14.29%, 'R': 28.57%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 14.29%, 'G': 7.14%, 'H': 0%, 'I': 0%, 'L': 0%, 'K': 0%, 'M': 0%, 'F': 0%, 'P': 14.29%, 'S': 7.14%, 'T': 7.14%, 'W': 0%, 'Y': 7.14%, 'V': 0%

Missing Amino Acid(s)

C, D, F, H, I, K, L, M, N, Q, V, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

G, S, T, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1645.8 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	14.286	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	73.121	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-1.986	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.565	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.987	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.001	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.071, 0.286, 0.286 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.071	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	1490, 1490	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

F.oxysporum

4.2 Antimicrobial Activity

Antimicrobial, Fungicide

4.3 Enzymatic Activity

Glycosidase, Hydrolase

4.4 Inhibitory Effect

Protein synthesis inhibitor

4.5 Other Biological Activity

Toxin, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Parkash A, Ng TB, Tso WW, et al. Isolation and characterization of luffacylin, a ribosome inactivating peptide with anti-fungal activity from sponge gourd (Luffa cylindrica) seeds. Peptides. 2002;23(6):1019-24. Published 2002 Jun. doi:10.1016/s0196-9781(02)00045-1

PMID: 12126727

5.2 Protein Sequence Databases

UniProt: P84073

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P84073

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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