AMPDB_35114 | Defensin-A

PEPTIDE SUMMARY

Defensin-A

1 General Description

AMPDB ID: AMPDB_35114

Protein Names: Defensin-A

Protein Family: Invertebrate defensin family; Type 1 subfamily

Gene Name: Nil

Source Organism: Anomala cuprea (Cupreous chafer beetle)

Protein Length: 43 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

VTCDLLSFEAKGFAANHSICAAHCLAIGRKGGSCQNGVCVCRN

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 6, 'R': 2, 'N': 3, 'D': 1, 'C': 6, 'Q': 1, 'E': 1, 'G': 5, 'H': 2, 'I': 2, 'L': 3, 'K': 2, 'M': 0, 'F': 2, 'P': 0, 'S': 3, 'T': 1, 'W': 0, 'Y': 0, 'V': 3

Frequencies of Amino Acids

'A': 13.95%, 'R': 4.65%, 'N': 6.98%, 'D': 2.33%, 'C': 13.95%, 'Q': 2.33%, 'E': 2.33%, 'G': 11.63%, 'H': 4.65%, 'I': 4.65%, 'L': 6.98%, 'K': 4.65%, 'M': 0%, 'F': 4.65%, 'P': 0%, 'S': 6.98%, 'T': 2.33%, 'W': 0%, 'Y': 0%, 'V': 6.98%

Missing Amino Acid(s)

M, P, W, Y

Most Occurring Amino Acid(s)

A, C

Less Occurring Amino Acid(s)

D, E, Q, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	4426.12 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	79.535	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	17.147	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.351	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.407	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.128	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.81	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.233, 0.256, 0.233 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.047	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 375	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.megaterium, B.subtilis (Gram-positive), E.coli (Gram-negative), M.luteus (Gram-negative), P.aeruginosa (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Yamauchi H, Yamauchi H. Two novel insect defensins from larvae of the cupreous chafer, Anomala cuprea: purification, amino acid sequences and antibacterial activity. Insect Biochem Mol Biol. 2001;32(1):75-84. Published 2001 Dec. doi:10.1016/s0965-1748(01)00082-0

PMID: 11719071

5.2 Protein Sequence Databases

UniProt: P83669

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P83669

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR017982, IPR001542, IPR003614, IPR036574

PANTHER: Not found

PROSITE: PS51378

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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