AMPDB_34961 | Defensin-A
PEPTIDE SUMMARY
Defensin-A
1 General Description
AMPDB ID: AMPDB_34961
Protein Names: Defensin-A
Protein Family: Invertebrate defensin family; Type 2 subfamily
Gene Name: Nil
Protein Length: 37 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
GFGCPNDYPCHRHCKSIPGRXGGYCGGXHRLRCTCYR
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 0, 'R': 5, 'N': 1, 'D': 1, 'C': 6, 'Q': 0, 'E': 0, 'G': 7, 'H': 3, 'I': 1, 'L': 1, 'K': 1, 'M': 0, 'F': 1, 'P': 3, 'S': 1, 'T': 1, 'W': 0, 'Y': 3, 'V': 0
Frequencies of Amino Acids
'A': 0%, 'R': 13.51%, 'N': 2.7%, 'D': 2.7%, 'C': 16.22%, 'Q': 0%, 'E': 0%, 'G': 18.92%, 'H': 8.11%, 'I': 2.7%, 'L': 2.7%, 'K': 2.7%, 'M': 0%, 'F': 2.7%, 'P': 8.11%, 'S': 2.7%, 'T': 2.7%, 'W': 0%, 'Y': 8.11%, 'V': 0%
Missing Amino Acid(s)
A, E, M, Q, V, W
Most Occurring Amino Acid(s)
G
Less Occurring Amino Acid(s)
D, F, I, K, L, N, S, T
Hydrophobic Amino Acid(s) Count
13
Hydrophilic Amino Acid(s) Count
22
Basic Amino Acid(s) Count
1
Acidic Amino Acid(s) Count
9
Modified Amino Acid(s) Count
{'X': 2}
Modified Amino Acid(s) Frequencies
{'X': 0.05405405405405406}
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 3928.5 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 21.081 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 43.292 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.808 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.459 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 8.864 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 4.896 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.162, 0.324, 0.027 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.108 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 4470, 4845 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
M.luteus (Gram-negative)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Defensin, Anti-gram-negative
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Charlet M, Chernysh S, Philippe H, et al. Innate immunity. Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis. J Biol Chem. 1996;271(36):21808-13. Published 1996 Sep 6. doi:10.1074/jbc.271.36.21808
PMID: 8702979
5.2 Protein Sequence Databases
UniProt: P81610
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P81610
5.4 Nucleotide Sequence Databases
No entries found in GenBank or EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR001542, IPR036574
PANTHER: Not found
PROSITE: PS51378
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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