AMPDB_34936 | Rugosin-B

PEPTIDE SUMMARY

Rugosin-B

1 General Description

AMPDB ID: AMPDB_34936

Protein Names: Rugosin-B

Protein Family: Frog skin active peptide (FSAP) family; Brevinin subfamily

Gene Name: Nil

Source Organism: Glandirana rugosa (Japanese wrinkled frog) (Rana rugosa)

Protein Length: 33 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

SLFSLIKAGAKFLGKNLLKQGAQYAACKVSKEC

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 5, 'R': 0, 'N': 1, 'D': 0, 'C': 2, 'Q': 2, 'E': 1, 'G': 3, 'H': 0, 'I': 1, 'L': 5, 'K': 6, 'M': 0, 'F': 2, 'P': 0, 'S': 3, 'T': 0, 'W': 0, 'Y': 1, 'V': 1

Frequencies of Amino Acids

'A': 15.15%, 'R': 0%, 'N': 3.03%, 'D': 0%, 'C': 6.06%, 'Q': 6.06%, 'E': 3.03%, 'G': 9.09%, 'H': 0%, 'I': 3.03%, 'L': 15.15%, 'K': 18.18%, 'M': 0%, 'F': 6.06%, 'P': 0%, 'S': 9.09%, 'T': 0%, 'W': 0%, 'Y': 3.03%, 'V': 3.03%

Missing Amino Acid(s)

D, H, M, P, R, T, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

E, I, N, V, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3516.22 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	94.849	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	32.958	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.152	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.602	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.299	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	4.873	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.303, 0.212, 0.333 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.091	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	1490, 1615	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Suzuki S, Ohe Y, Okubo T, et al. Isolation and characterization of novel antimicrobial peptides, rugosins A, B and C, from the skin of the frog, Rana rugosa. Biochem Biophys Res Commun. 1995;212(1):249-54. Published 1995 Jul 6. doi:10.1006/bbrc.1995.1963

PMID: 7612013

5.2 Protein Sequence Databases

UniProt: P80955

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P80955

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR012521

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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