AMPDB_34932 | Antimicrobial peptide eNAP-1
PEPTIDE SUMMARY
Antimicrobial peptide eNAP-1
1 General Description
AMPDB ID: AMPDB_34932
Protein Names: Antimicrobial peptide eNAP-1
Protein Family: Granulin family
Gene Name: Nil
Source Organism: Equus caballus (Horse)
Protein Length: 46 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
DVQCGEGHFCHDXQTCCRASQGGXACCPYSQGVCCADQRHCCPVGF
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 3, 'R': 2, 'N': 0, 'D': 3, 'C': 10, 'Q': 5, 'E': 1, 'G': 6, 'H': 3, 'I': 0, 'L': 0, 'K': 0, 'M': 0, 'F': 2, 'P': 2, 'S': 2, 'T': 1, 'W': 0, 'Y': 1, 'V': 3
Frequencies of Amino Acids
'A': 6.52%, 'R': 4.35%, 'N': 0%, 'D': 6.52%, 'C': 21.74%, 'Q': 10.87%, 'E': 2.17%, 'G': 13.04%, 'H': 6.52%, 'I': 0%, 'L': 0%, 'K': 0%, 'M': 0%, 'F': 4.35%, 'P': 4.35%, 'S': 4.35%, 'T': 2.17%, 'W': 0%, 'Y': 2.17%, 'V': 6.52%
Missing Amino Acid(s)
I, K, L, M, N, W
Most Occurring Amino Acid(s)
C
Less Occurring Amino Acid(s)
E, T, Y
Hydrophobic Amino Acid(s) Count
16
Hydrophilic Amino Acid(s) Count
28
Basic Amino Acid(s) Count
4
Acidic Amino Acid(s) Count
5
Modified Amino Acid(s) Count
{'X': 2}
Modified Amino Acid(s) Frequencies
{'X': 0.043478260869565216}
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 4668.21 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 25.435 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 45.002 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.233 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.44 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 6.182 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) -2.347 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.13, 0.217, 0.087 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.065 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 1490, 2115 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
Gram Negative Bacteria and Gram Positive Bacteria
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Couto MA, Harwig SS, Cullor JS, et al. Identification of eNAP-1, an antimicrobial peptide from equine neutrophils. Infect Immun. 1992;60(8):3065-71. Published 1992 Aug. doi:10.1128/iai.60.8.3065-3071.1992
PMID: 1639474
5.2 Protein Sequence Databases
UniProt: P80930
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P80930
5.4 Nucleotide Sequence Databases
No entries found in GenBank or EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR000118, IPR037277
PANTHER: Not found
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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