AMPDB_34898 | Aurein-2.1

PEPTIDE SUMMARY

Aurein-2.1

1 General Description

AMPDB ID: AMPDB_34898

Protein Names: Aurein-2.1 [Cleaved into: Aurein-2.1.1]

Protein Family: Frog skin active peptide (FSAP) family; Aurein subfamily

Gene Name: Nil

Source Organism: Ranoidea raniformis (Southern bell frog) (Litoria raniformis)

Protein Length: 16 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GLLDIVKKVVGAFGSL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 0, 'D': 1, 'C': 0, 'Q': 0, 'E': 0, 'G': 3, 'H': 0, 'I': 1, 'L': 3, 'K': 2, 'M': 0, 'F': 1, 'P': 0, 'S': 1, 'T': 0, 'W': 0, 'Y': 0, 'V': 3

Frequencies of Amino Acids

'A': 6.25%, 'R': 0%, 'N': 0%, 'D': 6.25%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 18.75%, 'H': 0%, 'I': 6.25%, 'L': 18.75%, 'K': 12.5%, 'M': 0%, 'F': 6.25%, 'P': 0%, 'S': 6.25%, 'T': 0%, 'W': 0%, 'Y': 0%, 'V': 18.75%

Missing Amino Acid(s)

C, E, H, M, N, P, Q, R, T, W, Y

Most Occurring Amino Acid(s)

G, L, V

Less Occurring Amino Acid(s)

A, D, F, I, S

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1615.98 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	158.125	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	-13.65	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	1.238	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.569	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.537	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.998	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.5, 0.25, 0.25 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.063	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.cereus (Gram-positive), L.innocua (Gram-positive), L.lactis (Gram-positive), M.luteus (Gram-negative), S.epidermidis (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Rozek T, Wegener KL, Bowie JH, et al. The antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. Eur J Biochem. 2000;267(17):5330-41. Published 2000 Sep. doi:10.1046/j.1432-1327.2000.01536.x

PMID: 10951191

5.2 Protein Sequence Databases

UniProt: P69016

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P69016

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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