AMPDB_34842 | Bacteriocin helveticin-J

PEPTIDE SUMMARY

Bacteriocin helveticin-J

1 General Description

AMPDB ID: AMPDB_34842

Protein Names: Bacteriocin helveticin-J

Protein Family: Nil

Gene Name: hlv

Source Organism: Lactobacillus helveticus (Lactobacillus suntoryeus)

Protein Length: 333 AA

Protein Existence: Predicted

2 Protein Sequence & Composition

2.1 Sequence

MKHLNETTNVRILSQFDMDTGYQAVVQKGNVGSKYVYGLQLRKGATTILRGYRGSKINNPILELSGQAGGHTQTWEFAGDRKDINGEERAGQWFIGVKPSKIEGSKIIWAKQIARVDLRNQMGPHYSNTDFPRLSYLNRAGSNPFAGNKMTHAEAAVSPDYTKFLIATVENNCIGHFTIYNLDTINEKLDEKGNSEDVNLETVKYEDSFIIDNLYGDDNNSIVNSIQGYDLDNDGNIYISSQKAPDFDGSYYAHHKQIVKIPYYARSKESEDQWRAVNLSEFGGLDIPGKHSEVESIQIIGENHCYLTVAYHSKNKAGENKTTLNEIYELSWN

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 19, 'R': 12, 'N': 29, 'D': 21, 'C': 2, 'Q': 14, 'E': 22, 'G': 29, 'H': 10, 'I': 27, 'L': 21, 'K': 23, 'M': 4, 'F': 10, 'P': 9, 'S': 24, 'T': 17, 'W': 5, 'Y': 19, 'V': 16

Frequencies of Amino Acids

'A': 5.71%, 'R': 3.6%, 'N': 8.71%, 'D': 6.31%, 'C': 0.6%, 'Q': 4.2%, 'E': 6.61%, 'G': 8.71%, 'H': 3%, 'I': 8.11%, 'L': 6.31%, 'K': 6.91%, 'M': 1.2%, 'F': 3%, 'P': 2.7%, 'S': 7.21%, 'T': 5.11%, 'W': 1.5%, 'Y': 5.71%, 'V': 4.8%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

G, N

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

140

Hydrophilic Amino Acid(s) Count

193

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	37511.6 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	75.856	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	27.376	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.66	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.728	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.006	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-7.191	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.294, 0.273, 0.198 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.102	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	55810, 55935	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Lactobacillus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Joerger MC, Klaenhammer TR, Klaenhammer TR. Cloning, expression, and nucleotide sequence of the Lactobacillus helveticus 481 gene encoding the bacteriocin helveticin J. J Bacteriol. 1990;172(11):6339-47. Published 1990 Nov. doi:10.1128/jb.172.11.6339-6347.1990

PMID: 2228964

5.2 Protein Sequence Databases

UniProt: P22294

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P22294

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	M59360	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_025006474.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR035280

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

Download