AMPDB_34828 | Bactericidin B-4

PEPTIDE SUMMARY

Bactericidin B-4

1 General Description

AMPDB ID: AMPDB_34828

Protein Names: Bactericidin B-4 (Cecropin-like peptide B-4)

Protein Family: Cecropin family

Gene Name: Nil

Source Organism: Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)

Protein Length: 37 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

WNPFKELERAGQRVRDAIISAAPAVATVGQAAAIARG

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 10, 'R': 4, 'N': 1, 'D': 1, 'C': 0, 'Q': 2, 'E': 2, 'G': 3, 'H': 0, 'I': 3, 'L': 1, 'K': 1, 'M': 0, 'F': 1, 'P': 2, 'S': 1, 'T': 1, 'W': 1, 'Y': 0, 'V': 3

Frequencies of Amino Acids

'A': 27.03%, 'R': 10.81%, 'N': 2.7%, 'D': 2.7%, 'C': 0%, 'Q': 5.41%, 'E': 5.41%, 'G': 8.11%, 'H': 0%, 'I': 8.11%, 'L': 2.7%, 'K': 2.7%, 'M': 0%, 'F': 2.7%, 'P': 5.41%, 'S': 2.7%, 'T': 2.7%, 'W': 2.7%, 'Y': 0%, 'V': 8.11%

Missing Amino Acid(s)

C, H, M, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

D, F, K, L, N, S, T, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3862.41 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	92.703	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	19.251	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.027	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.875	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.305	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.002	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.243, 0.189, 0.351 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.054	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Dickinson L, Russell V, Dunn PE, et al. A family of bacteria-regulated, cecropin D-like peptides from Manduca sexta. J Biol Chem. 1988;263(36):19424-9. Published 1988 Dec 25. doi:

PMID: 3143727

5.2 Protein Sequence Databases

UniProt: P14664

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P14664

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR000875

PANTHER: Not found

PROSITE: PS00268

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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