AMPDB_34816 | Antimicrobial peptide AmAMP1

PEPTIDE SUMMARY

Antimicrobial peptide AmAMP1

1 General Description

AMPDB ID: AMPDB_34816

Protein Names: Antimicrobial peptide AmAMP1

Protein Family: Coral AMP family

Gene Name: Nil

Source Organism: Acropora millepora (Staghorn coral) (Heteropora millepora)

Protein Length: 117 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MPSIRVLFVLLAVILLFMEVKMTSAASIVKDVDEDETLENEDGEAMENSWPWHGVEDTSDYSDLSDLANSEKRGTCIDLGSRLYCKLIRRRGMCRSRSHRARIAMMRCERSCGRCHL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 7, 'R': 13, 'N': 3, 'D': 9, 'C': 6, 'Q': 0, 'E': 10, 'G': 6, 'H': 3, 'I': 6, 'L': 12, 'K': 4, 'M': 7, 'F': 2, 'P': 2, 'S': 12, 'T': 4, 'W': 2, 'Y': 2, 'V': 7

Frequencies of Amino Acids

'A': 5.98%, 'R': 11.11%, 'N': 2.56%, 'D': 7.69%, 'C': 5.13%, 'Q': 0%, 'E': 8.55%, 'G': 5.13%, 'H': 2.56%, 'I': 5.13%, 'L': 10.26%, 'K': 3.42%, 'M': 5.98%, 'F': 1.71%, 'P': 1.71%, 'S': 10.26%, 'T': 3.42%, 'W': 1.71%, 'Y': 1.71%, 'V': 5.98%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

F, P, W, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	13386.4 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	83.333	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	51.463	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.296	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.813	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.247	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-2.082	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.265, 0.197, 0.308 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.051	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	13980, 14355	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Acinetobacter spec. (Gram-negative), B.algicola (Not characterize), B.megaterium, Coral, E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Mason B, Cooke I, Moya A, et al. AmAMP1 from Acropora millepora and damicornin define a family of coral-specific antimicrobial peptides related to the Shk toxins of sea anemones. Dev Comp Immunol. 2021;114:103866. Published 2021 Jan. doi:10.1016/j.dci.2020.103866

PMID: 32937163

5.2 Protein Sequence Databases

UniProt: P0DUG2

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DUG2

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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